Alteplase and brain herniation Patient Reports March 19, 2010

Alteplase Side Effects Report #4716953-8
Alteplase side effect was reported by a Consumer or non-health professional from UNITED STATES on June 29, 2005. Male patient, 47 years of age, was diagnosed with thrombosis in device, clonus and was treated with Alteplase. After drug was administered, patient experienced the following side effects: basilar artery thrombosis, brain herniation, brain oedema, brain stem syndrome, carotid artery occlusion, cerebral haemorrhage, cerebral infarction, coma, corneal reflex decreased. Alteplase dosage: INTERMITTENT THROMBOLYSIS DOSES RANGING FROM 50 TO 100 MG (NR, INTERMITTENT THROMBOLYSIS), IV. During the same period patient was treated with ASPIRIN, MIDAZOLAM, WARFARIN, CLOPIDOGREL BISULPHATE, HEPARIN, PHOSPHENYTOIN. Patient died.

Alteplase Side Effects Report #5424707-2
Alteplase side effect was reported by a Pharmacist from UNITED STATES on Aug 22, 2007. Male patient, 80 years of age, weighting 160.1 lb, was diagnosed with ischaemic stroke and was treated with Alteplase. After drug was administered, patient experienced the following side effects: brain herniation, cerebral haemorrhage, subarachnoid haemorrhage. Alteplase dosage: 7.2MG ONCE IV. Patient died on 06/11/2007.

Alteplase Side Effects Report #5941513-0
Alteplase side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 03, 2008. Male patient, 49 years of age, weighting 330.7 lb, was diagnosed with deep vein thrombosis  and was treated with Alteplase. After drug was administered, patient experienced the following side effects: brain herniation, haemorrhage intracranial, pulmonary embolism . Alteplase dosage: 18MG OVER 12 HOURS IV DRIP. During the same period patient was treated with HEPARIN. Patient died on 10/17/2008.

Alteplase Side Effects Report #5951550-8
Alteplase side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 12, 2008. Male patient, 49 years of age, weighting 350.5 lb, was diagnosed with deep vein thrombosis  and was treated with Alteplase. After drug was administered, patient experienced the following side effects: brain herniation, cerebral haemorrhage, haemorrhage intracranial, pulmonary embolism , refusal of treatment by relative. Alteplase dosage: 18MG OVER 12 HOURS INTRAVENOUS DRIP. During the same period patient was treated with HEPARIN. Patient died on 10/17/2008.