Bosentan and asthenia Patient Reports March 21, 2010

Bosentan Side Effects Report #4586772-4
Bosentan side effect was reported by a Pharmacist from on Feb 17, 2005. Male patient, 79 years of age, weighting 200.6 lb, was diagnosed with pulmonary hypertension , heart valve replacement and was treated with Bosentan. After drug was administered, patient experienced the following side effects: asthenia, decreased appetite, fluid retention, international normalised ratio increased, liver function test abnormal, malaise, pneumonia . Bosentan dosage: unknown. During the same period patient was treated with WARFARIN NOT DOCUMENTED NOT DOCUMENTED. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #4559588-2
Bosentan side effect was reported by a Physician from on Jan 13, 2005. Male patient, 63 years of age, weighting 162.7 lb, was diagnosed with pulmonary hypertension , connective tissue disorder  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: asthenia, nausea , weight decreased. Bosentan dosage: 125 + 62.5 MG, BID, ORAL. During the same period patient was treated with AZATHIOPRINE, PREDNISOLONE, OMEPRAZOLE, COLCHICINA. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #4560646-7
Bosentan side effect was reported by a Health Professional from on Jan 13, 2005. Male patient, 63 years of age, weighting 162.7 lb, was diagnosed with pulmonary hypertension , connective tissue disorder  and was treated with Bosentan. After drug was administered, patient experienced the following side effects: asthenia, nausea , weight decreased. Bosentan dosage: unknown. During the same period patient was treated with PREDNISOLONE, OMEPRAZOLE, COLCHICINA, AZATHIOPRINE. Patient was hospitalized. Patient recovered.