Busulfex and bone marrow transplant Patient Reports February 10, 2010

Busulfex Side Effects Report #5819581-6
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on July 07, 2008. Female patient, child 9 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, anorexia, bone marrow transplant , condition aggravated, cystitis haemorrhagic, diarrhoea, malaise, nausea , stomatitis. Busulfex dosage: 11.1 ML, INTRAVENOUS, 14.8 ML DAILY DOSE; INTRAVENOUS, 3.7 ML, DAILY DOSE; INTRAVENOUS. During the same period patient was treated with CYTARABINE, MELPHALAN, ETOPOSIDE, VALPROATE, METHOTREXATE, TACROLIMIS. Patient died.

Busulfex Side Effects Report #5871281-2
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 19, 2008. Male patient, child 7 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, bone marrow transplant , cystitis haemorrhagic, diarrhoea, malaise, nausea , sepsis , stomatitis. Busulfex dosage: 68 ML INTRAVENOUS. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, LENOGRASTIM, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5902789-9
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 17, 2008. Female patient, 67 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: abdominal pain upper, acute respiratory failure, anorexia, blood bilirubin increased, bone marrow transplant , bone marrow transplant rejection, cytomegalovirus viraemia, diarrhoea, enterobacter sepsis. Busulfex dosage: 24 ML, DAILY DOSE, INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient died.

Busulfex Side Effects Report #6030743-8
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Dec 24, 2008. Male patient, 65 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, bone marrow transplant , bone marrow transplant rejection, disease recurrence, malignant neoplasm progression, platelet count decreased, pneumonia , stomatitis. Busulfex dosage: 8 ML, QID INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient died on 01/05/2008.


Busulfex Side Effects Report #5800909-8
Busulfex side effect was reported by a Physician from JAPAN on June 20, 2008. Male patient, 64 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute myeloid leukaemia recurrent, anorexia, atrial tachycardia, atrioventricular block, bone marrow transplant , cytomegalovirus viraemia, diarrhoea, dysgeusia. Busulfex dosage: unknown. During the same period patient was treated with PHENYTOIN, NARTOGRASTIM, METHOTREXATE, TACROLIMUS, CYTARABINE, NOVANTRONE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5698111-6
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Female patient, 63 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , hepatic function abnormal, renal impairment. Busulfex dosage: 24 ML, INTRAVENOUS. During the same period patient was treated with TACROLIMUS. Patient recovered.

Busulfex Side Effects Report #5852712-0
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 07, 2008. Male patient, 63 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, bacterial sepsis, bifidobacterium infection, blood creatinine increased, blood urea increased, bone marrow transplant , bone marrow transplant rejection, bronchopulmonary aspergillosis, candida sepsis. Busulfex dosage: 24.9 ML, DAILY DOSE, INTRAVENOUS, 33.2 ML, DAILY DOSE; INTRAVENOUS, 8.3 ML, DAILY DOSE; SEE IMAGE. During the same period patient was treated with CYCLOSPORINE, FLUDARABINE PHOSPHATE, PHENYTOIN, METHYLPREDNISOLONE SUCCINATE, FLUDARABINE PHOSPHATE. Patient died.

Busulfex Side Effects Report #5769154-9
Busulfex side effect was reported by a Physician from JAPAN on May 29, 2008. Female patient, 62 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , cytomegalovirus infection , enterocolitis viral, graft versus host disease, pneumonia , stomatitis. Busulfex dosage: 28 ML, INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, LENOGRASTIM, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5743657-5
Busulfex side effect was reported by a Health Professional from JAPAN on May 08, 2008. Male patient, 60 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: adenoviral haemorrhagic cystitis, anorexia, bone marrow transplant , cytomegalovirus antigen positive, cytomegalovirus viraemia, graft versus host disease, liver disorder, nausea , nystagmus. Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, NEUPOGEN, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient recovered.


Busulfex Side Effects Report #5698159-1
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Male patient, 58 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: ascites, blister, blood bilirubin increased, bone marrow transplant , cystitis haemorrhagic, cytomegalovirus viraemia, diarrhoea, graft versus host disease, haematochezia. Busulfex dosage: 31.72 ML, INTRAVENOUS. During the same period patient was treated with NEUPOGEN. Patient was hospitalized. Patient died.

Busulfex Side Effects Report #5729836-1
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Apr 21, 2008. Male patient, 58 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , cerebral haemorrhage, diarrhoea, malaise, multi-organ failure, pneumonia , sepsis , shock. Busulfex dosage: 33.2 ML INTRAVENOUS; 16.6 ML INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, MELPHALAN, VALPROATE, METHOTREXATE. Patient was hospitalized. Patient died.

Busulfex Side Effects Report #5883707-9
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 27, 2008. Male patient, 58 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anorexia, aspartate aminotransferase increased, blood bilirubin increased, blood creatinine increased, blood potassium decreased, blood urea increased, bone marrow transplant , cerebral haemorrhage. Busulfex dosage: 33.2 ML, DAILY DOSE INTRAVENOUS; 16.6 ML, DAILY DOSE INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, MELPHALAN, VALPROATE, METHOTREXATE. Patient was hospitalized. Patient died on 11/30/2007.

Busulfex Side Effects Report #5743637-X
Busulfex side effect was reported by a Health Professional from JAPAN on May 08, 2008. Female patient, 57 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, alanine aminotransferase increased, anorexia, blood bilirubin increased, bone marrow transplant , bone marrow transplant rejection, platelet count decreased, sepsis . Busulfex dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, NEUPOGEN, METHOTREXATE, TACROLIMUS. Patient died.

Busulfex Side Effects Report #5782929-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on June 11, 2008. Female patient, 57 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , malaise, nausea , sepsis . Busulfex dosage: 30 ML, INTRAVENOUS. During the same period patient was treated with MELPHALAN. Patient died on 07/19/2006.


Busulfex Side Effects Report #5872400-4
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 20, 2008. Female patient, 57 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia recurrent, anorexia, bone marrow transplant , diarrhoea, febrile neutropenia, malaise, nausea , reticulocyte count decreased, stomatitis. Busulfex dosage: 30 ML, INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, LENOGRASTIM, METHOTREXATE, CYCLOSPORINE. Patient died.

Busulfex Side Effects Report #5895530-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 10, 2008. Female patient, 57 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, alanine aminotransferase increased, anorexia, aspartate aminotransferase increased, blood bilirubin increased, bone marrow transplant , sepsis . Busulfex dosage: 25.2 ML, DAILY DOSE, INTRAVENOUS. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient died.

Busulfex Side Effects Report #5698112-8
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Female patient, 55 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, bone marrow transplant , gastrointestinal haemorrhage, sepsis . Busulfex dosage: 30 ML, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5744162-2
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on May 08, 2008. Female patient, 55 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, alanine aminotransferase increased, anorexia, blood bilirubin increased, bone marrow transplant , bone marrow transplant rejection, gastrointestinal haemorrhage, nausea , platelet count decreased. Busulfex dosage: 30 ML, INTRAVENOUS. Patient was hospitalized. Patient died.

Busulfex Side Effects Report #5819439-2
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on July 08, 2008. Female patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , cytomegalovirus enterocolitis, graft versus host disease, stomatitis. Busulfex dosage: 156 ML, INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, FILGRASTIM, CYCLOSPORINE. Patient was hospitalized. Patient recovered.


Busulfex Side Effects Report #5886250-6
Busulfex side effect was reported by a Health Professional from JAPAN on Sept 01, 2008. Male patient, 53 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute myeloid leukaemia recurrent, anorexia, bone marrow transplant , diarrhoea, headache , malaise, nausea , pain in extremity. Busulfex dosage: 12 ML, INTRAVENOUS; 24 ML, DAILY: INTRAVENOUS; DAILY DOSE; INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, PHENYTOIN, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfex Side Effects Report #5819583-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on July 07, 2008. Male patient, 52 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anorexia, aspartate aminotransferase increased, blood lactate dehydrogenase increased, bone marrow transplant , catheter sepsis, convulsion, cystitis haemorrhagic, diarrhoea. Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, FLIGRASTIM, METHOTREXATE, TACROLIMUS, MYOPHENOLATE MOFETIL, MICAFUNGIN, GANCICLOVIR. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5984857-9
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Nov 18, 2008. Female patient, 52 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: adult t-cell lymphoma/leukaemia recurrent, anorexia, bone marrow transplant , cytomegalovirus viraemia, diarrhoea, hypokalaemia, malaise, nausea . Busulfex dosage: 6.4 ML, QD. During the same period patient was treated with DEPAKENE, FLUDARABINE PHOSPHATE, FILGRASTIM. Patient recovered.

Busulfex Side Effects Report #5893732-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 05, 2008. Female patient, 51 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, adult t-cell lymphoma/leukaemia recurrent, anorexia, bone marrow transplant , cytomegalovirus enterocolitis, malaise, stomatitis, vomiting. Busulfex dosage: 24 ML, INTRAVENOUS. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfex Side Effects Report #6072908-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Jan 22, 2009. Male patient, 51 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: blood bilirubin increased, bone marrow transplant , cardiac arrest , convulsion, graft versus host disease, melaena, no therapeutic response, toxic encephalopathy. Busulfex dosage: 200 MG, DAILY DOSE INTRAVENOUS. During the same period patient was treated with TACROLIMUS, VALPROATE, CYCLOPHOSPHAMIDE, FILGRASTIM, METHOTREXATE, CYCLOSPORINE. Patient died.


Busulfex Side Effects Report #5798829-0
Busulfex side effect was reported by a Health Professional from JAPAN on June 16, 2008. Female patient, 50 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , cytomegalovirus viraemia, enterocolitis, graft versus host disease, malaise, multi-organ failure, myelodysplastic syndrome. Busulfex dosage: 32 ML, INTRAVENOUS; 16 ML, DAILY DOSE; INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, MELPHALAN, METHOTREXATE, CYCLOSPORINE. Patient was hospitalized. Patient died.

Busulfex Side Effects Report #5974411-7
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Nov 17, 2008. Female patient, 50 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: abdominal pain , acute graft versus host disease, acute myeloid leukaemia, anorexia, bone marrow transplant , constipation , diarrhoea, febrile neutropenia, headache . Busulfex dosage: 6.67 ML, QID INTRAVENOUS. During the same period patient was treated with ENDOXAN NET, METHOTREXATE, DEPAKENE, FILGRASTIM, TACROLIMUS. Patient was hospitalized. Patient died on 06/16/2007.

Busulfex Side Effects Report #6016185-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Dec 09, 2008. Male patient, 50 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia recurrent, bone marrow transplant , cytomegalovirus viraemia, diarrhoea, hiccups, nausea , neutropenia, oedema, rash . Busulfex dosage: 8.2 ML, TID INTRAVENOUS : 8.2 ML,QID; INTRAVENOUS : 8.2 ML,QD;INTRAVENOUS. During the same period patient was treated with CYTARABINE, VALPROATE, CYCLOPHOSPHAMIDE, NARTOGRASTIM, TACROLIMUS. Patient was hospitalized and became disabled. Patient recovered.

Busulfex Side Effects Report #5906670-0
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 16, 2008. Male patient, child 5 years of age, was diagnosed with stem cell transplant, mucous membrane disorder, pyrexia, pain , graft versus host disease and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease in skin, blood culture positive, blood pressure decreased, bone marrow transplant , cardiac arrest , cardiac failure acute, cardiovascular disorder, coagulopathy, condition aggravated. Busulfex dosage: 14 ML, INTRAVENOUS. During the same period patient was treated with MORPHINE, ACETAMINOPHEN, HYDROXYZINE, MICAFUNGIN, PREDNISOLONE SUCCINATE, PREDNISOLONE SUCCINATE, TACROLIMUS, MYCOPHENOLATE MOFETIL. Patient died.

Busulfex Side Effects Report #5819511-7
Busulfex side effect was reported by a Health Professional from JAPAN on July 08, 2008. Female patient, 47 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , diarrhoea, gastrointestinal haemorrhage, malaise, multi-organ failure, nausea . Busulfex dosage: 6 ML INTRAVENOUS; 24 ML, DAILY DOSE; INTRAVENOUS; 18 ML, DAILY DOSE; INTRAVENOUS. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, NARTOGRASTIM, METHOTREXATE, TACROLIMUS. Patient died.


Busulfex Side Effects Report #6016856-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Dec 09, 2008. Male patient, 39 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , bone marrow transplant rejection, constipation , diarrhoea, gamma-glutamyltransferase increased, hypertension, infection , nausea . Busulfex dosage: 8 ML, TID; 8 ML, QID, INTRAVENOUS; 8 ML, TID, INTRAVENOUS. During the same period patient was treated with METHOTREXATE, FLUDARABINE PHOSPHATE, DEPAKENE, ANTILYMPHOCYTE IMMUNOGLOBULIN, NEUTROGIN, CYCLOSPORINE. Patient recovered.

Busulfex Side Effects Report #5852711-9
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 07, 2008. Male patient, 34 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, adenoviral haemorrhagic cystitis, anorexia, ascites, bone marrow failure, bone marrow transplant , candida sepsis, cytomegalovirus viraemia, diarrhoea. Busulfex dosage: 22.5 ML, INTRAVENOUS, 30 ML, DAILY DOSE; INTRAVENOUS, 7.5 ML, DAILY DOSE; INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, NARTOGRASTIM, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient died.

Busulfex Side Effects Report #5927296-9
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Oct 03, 2008. Male patient, 33 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , malignant neoplasm progression, t-cell lymphoma recurrent. Busulfex dosage: 10 MG, QID IV DRIP. During the same period patient was treated with CYTARABINE, FLUDARABINE PHOSPHATE, CYCLOPHOSPHAMIDE, PHENYTOIN, NEUTROGIN, METHOTREXATE, TACROLIMUS, METHYLPREDNISOLONE. Patient recovered.

Busulfex Side Effects Report #5852723-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 08, 2008. Female patient, 32 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, altered state of consciousness, anorexia, blister, blood bilirubin increased, bone marrow transplant , bone marrow transplant rejection, brain abscess, cytomegalovirus viraemia. Busulfex dosage: 19.2 ML, DAILY DOSE INTRAVENOUS. During the same period patient was treated with NARTOGRASTIM, TACROLIMUS, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, ANTILYMPHOCYTE IMMUNOGLOBULIN, MELPHALAN. Patient died on 08/20/2007.

Busulfex Side Effects Report #5906671-2
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 19, 2008. Female patient, 31 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute lymphocytic leukaemia recurrent, bone marrow transplant , diarrhoea, nausea , stomatitis. Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, LENOGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.


Busulfex Side Effects Report #5698113-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Male patient, 30 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , pseudomonal sepsis. Busulfex dosage: unknown. Patient recovered.

Busulfex Side Effects Report #5698158-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Male patient, 30 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anaemia, ascites, bone marrow transplant , platelet count decreased, renal impairment, thrombotic microangiopathy, weight increased. Busulfex dosage: unknown. During the same period patient was treated with CYCLOSPORINE, NEUPOGEN. Patient died.

Busulfex Side Effects Report #5743654-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on May 08, 2008. Male patient, 30 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood creatinine increased, bone marrow failure, bone marrow transplant , cerebrovascular accident, delayed engraftment, diarrhoea, febrile neutropenia. Busulfex dosage: 34.8 ML. During the same period patient was treated with CYCLOPHOSPHAMIDE, NEUPOGEN, METHOTREXATE, TACROLIMUS, VALPROATE. Patient died.

Busulfex Side Effects Report #5698188-8
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Female patient, 29 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , bronchopulmonary aspergillosis, serratia sepsis, stomatitis, venoocclusive liver disease. Busulfex dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, LENOGRATIM, METHOTREXATE, CYCLOSPORINE. Patient recovered.

Busulfex Side Effects Report #5698126-8
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Male patient, 25 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , bone marrow transplant rejection, perianal abscess, pneumonia staphylococcal, staphylococcal pharyngitis, stomatitis, surgical procedure repeated. Busulfex dosage: unknown. Patient died.


Busulfex Side Effects Report #5877273-1
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 26, 2008. Female patient, child 2 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute myeloid leukaemia recurrent, anorexia, bone marrow transplant , herpes virus infection, liver disorder, malaise, nausea . Busulfex dosage: 9.6 ML, UNK, INTRAVENOUS. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, LENOGRASTIM, NARTOGRASTIM, METHOTREXATE. Patient died on 10/07/2007.

Busulfex Side Effects Report #5782932-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on June 11, 2008. Male patient, 17 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , diarrhoea, malaise, nausea , sepsis , stomatitis. Busulfex dosage: 40 ML, INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, LENOGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfex Side Effects Report #5878628-1
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 26, 2008. Male patient, 17 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , bone marrow transplant rejection, cardiac failure, chronic graft versus host disease, cytomegalovirus viraemia, febrile neutropenia, fungal infection , pancreatitis, pneumonia staphylococcal. Busulfex dosage: 36 ML, INTRAVENOUS. During the same period patient was treated with TACROLIMUS, VALPROATE, FILGRASTIM, METHOTREXATE, CYCLOPHOSPAMIDE. Patient was hospitalized. Patient died on 08/20/2007.

Busulfex Side Effects Report #5920078-3
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 29, 2008. Male patient, 16 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , diarrhoea, hyperglycaemia, liver disorder, nausea , sepsis , sialoadenitis, stomatitis. Busulfex dosage: unknown. During the same period patient was treated with ALKERAN, VALPROATE, NEUTROGIN, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5958873-7
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Nov 06, 2008. Male patient, 16 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, bone marrow transplant , bone marrow transplant rejection, cardiac failure, chronic graft versus host disease, cytomegalovirus viraemia, fungal infection , haemoglobin increased. Busulfex dosage: 36 ML, INTRAVENOUS. During the same period patient was treated with TACROLIMUS, VALPROATE, FILGRASTIM, METHOTREXATE, CYCLOPHOSPHAMIDE, LASIX. Patient was hospitalized. Patient died on 08/20/2007.

Busulfex Side Effects Report #5698179-7
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Male patient, 15 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , haematuria, proteinuria. Busulfex dosage: unknown. During the same period patient was treated with NEUPOGEN. Patient recovered.

Busulfex Side Effects Report #5744161-0
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on May 08, 2008. Male patient, 15 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bk virus infection, bone marrow transplant , cytomegalovirus infection , diarrhoea, febrile neutropenia, graft versus host disease, haematuria, jaundice . Busulfex dosage: unknown. During the same period patient was treated with NEUPOGEN. Patient recovered.

Busulfex Side Effects Report #5356575-1
Busulfex side effect was reported by a Health Professional from JAPAN on May 29, 2007. Female patient, 13 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: adenovirus infection, bk virus infection, blood culture positive, bone marrow transplant , diarrhoea, enterococcal infection, fungal infection , histiocytosis haematophagic, hydronephrosis. Busulfex dosage: unknown. During the same period patient was treated with VALPROATE. Patient died on 03/28/2007.

Busulfex Side Effects Report #5385511-7
Busulfex side effect was reported by a Health Professional from JAPAN on June 26, 2007. Female patient, 13 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: adenovirus infection, anorexia, bk virus infection, bladder disorder, bone marrow transplant , diarrhoea, enterococcal infection, fungal infection , haematoma. Busulfex dosage: unknown. During the same period patient was treated with VALPROATE. Patient died on 03/28/2007.

Busulfex Side Effects Report #5406808-8
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on July 19, 2007. Female patient, 13 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: adenovirus infection, anaemia, anorexia, ascites, bk virus infection, bone marrow transplant , bone marrow transplant rejection, cystitis haemorrhagic, diarrhoea. Busulfex dosage: unknown. During the same period patient was treated with VALPROATE, FLUDARABINE PHOSPHATE, THIOTEPA, METHOTREXATE, CYCLOSPORINE, FILGRASTIM. Patient died on 03/28/2007.


Busulfex Side Effects Report #5822815-5
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on July 14, 2008. Female patient, 13 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , febrile neutropenia, malaise, stomatitis, transplant rejection. Busulfex dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, ANTILYMPHOCYTE IMMUNOGLOBULIN, PHENYTOIN, FILGRASTIM, METHOTREXATE, CYCLOSPORINE. Patient recovered.

Busulfex Side Effects Report #5900852-X
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 16, 2008. Female patient, 13 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute lymphocytic leukaemia recurrent, anorexia, bone marrow transplant , bone marrow transplant rejection, febrile neutropenia, gamma-glutamyltransferase increased, hypokalaemia, malaise, pyrexia. Busulfex dosage: 58 MG. During the same period patient was treated with CYCLOPHOSPHAMIDE, ANTILYMPHOCYTE IMMUNOGOLBULIN, PHENYTOIN, FILGRASTIM, METHOTREXATE, CYCLOSPORINE. Patient recovered.

Busulfex Side Effects Report #5878642-6
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 26, 2008. Female patient, child 12 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, bone marrow transplant , clostridial infection, diarrhoea, malaise, nausea , rhabdomyosarcoma recurrent, stomatitis. Busulfex dosage: 9 ML, DAILY DOSE INTRAVENOUS; 18 ML, DAILY DOSE; INTRAVENOUS; DF, DAILY DOSE; INTRAVENOUS. During the same period patient was treated with MELPHALAN, PHENYTOIN, FILGRASTIM, CYCLOSPORINE, METHYLPREDNISOLONE. Patient recovered.

Busulfex Side Effects Report #5729834-8
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Apr 21, 2008. Male patient was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , dermatitis, diarrhoea, febrile neutropenia, infection , mucosal inflammation. Busulfex dosage: 6 ML INTRAVENOUS; INTRAVENOUS. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE, CLONAZEPAM, LENOGRASTIM, NARTOGRASTIM, METHOTREXATE. Patient recovered.

Busulfex Side Effects Report #5989260-3
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Nov 25, 2008. Female patient was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute lymphocytic leukaemia recurrent, bone marrow transplant , nausea , neutropenia, pyrexia, respiratory disorder, sepsis , stomatitis, venoocclusive liver disease. Busulfex dosage: 2.4 ML, INTRAVENOUS. During the same period patient was treated with CLONAZEPAM, ZONISAMIDE, ETOPOSIDE, CYCLOPHOSPHAMIDE, FILGRASTIM, METHOTREXATE, TACROLIMUS. Patient recovered.

Busulfex Side Effects Report #4585875-8
Busulfex side effect was reported by a Physician from on Feb 03, 2005. Male patient, 39 years of age, was diagnosed with non-hodgkin's lymphoma and was treated with Busulfex. After drug was administered, patient experienced the following side effects: ascites, blood bilirubin increased, bone marrow transplant , coagulopathy, haemorrhage intracranial, hepatic function abnormal, pulmonary haemorrhage, weight increased. Busulfex dosage: 168MG/DAY (42MG/DOSE X 4 TIMES)-IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, PHENYTOIN, ALLOPURINOL, ANTIFUNGAL AGENTS. Patient died on 01/19/2004.

Busulfex Side Effects Report #4585874-6
Busulfex side effect was reported by a Physician from on Feb 03, 2005. Male patient, 59 years of age, was diagnosed with multiple myeloma  and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , cardiac failure congestive, sepsis , staphylococcal bacteraemia. Busulfex dosage: 264MG/DAY (66MG/DOSE X 4 TIMES)-IV. During the same period patient was treated with FLUDARABINE PHOSPHATE, ATGAM, PHENYTOIN, ZOFRAN, ALLOPURINOL. Patient died on 12/05/2003.

Busulfex Side Effects Report #4585888-6
Busulfex side effect was reported by a Physician from on Feb 03, 2005. Male patient, 45 years of age, was diagnosed with acute myeloid leukaemia and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , febrile neutropenia, hypotension, septic shock. Busulfex dosage: 188MG/DAY (47MG/DOSE X 4 TIMES)-IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, PHENYTOIN, ALLOPURINOL, ANTIFUNGAL AGENTS. Patient died on 01/21/2004.

Busulfex Side Effects Report #4585902-8
Busulfex side effect was reported by a Physician from on Feb 03, 2005. Female patient, 34 years of age, was diagnosed with acute myeloid leukaemia and was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , febrile neutropenia, septic shock. Busulfex dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, PHENYTOIN, ALLOPURINOL, ANTIFUNGAL AGENTS. Patient died on 01/28/2004.

Busulfex Side Effects Report #4585868-0
Busulfex side effect was reported by a Physician from on Feb 03, 2005. Male patient, 27 years of age, was diagnosed with acute leukaemia and was treated with Busulfex. After drug was administered, patient experienced the following side effects: azotaemia, bone marrow transplant , haemodialysis, renal failure. Busulfex dosage: 208/MG/DAY (52MG/DOSE X 4 TIMES)-IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, PHENYTOIN, ZOFRAN, ANTIBIOTICS, IMMUNOSUPPRESSANTS. Patient was hospitalized. Patient recovered.


Busulfex Side Effects Report #5849784-6
Busulfex side effect was reported by a Health Professional from JAPAN on Aug 04, 2008. Female patient, 40 years of age, was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute lymphocytic leukaemia recurrent, alanine aminotransferase increased, anorexia, aspartate aminotransferase increased, blood bilirubin increased, blood chloride increased, blood pressure increased, bone marrow transplant , diarrhoea. Busulfex dosage: 25.6ML, INTRAVENOUS. During the same period patient was treated with CYTARABINE, CYCLOPHOSPHAMIDE, VALPROATE, LENOGRASTIM, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient died.

Busulfex Side Effects Report #4627441-1
Busulfex side effect was reported by a Consumer or non-health professional from on Mar 23, 2005. Female patient, 20 years of age, was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant , cardiomyopathy , chest pain , electrocardiogram st segment depression, heart rate increased. Busulfex dosage: 144MG/D (36MG/DOS X 4TIMES) - (16 DOSES TOTAL ADMINISTERED); DR. During the same period patient was treated with CYCLOPHOSPHAMIDE, MESNA, BUSERELIN ACETATE, SULFAMETHOXAZOLE AND TRIMETHOPRIM, FLUCONAZOLE, PHENYTOIN, SENNOSIDE, CIPROFLOXACIN HYDROCHLORIDE. Patient recovered.