Busulfex and liver disorder Patient Reports February 10, 2010

Busulfex Side Effects Report #5849766-4
Busulfex side effect was reported by a Health Professional from JAPAN on Aug 08, 2008. Male patient, child 9 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, gastritis, hypercalcaemia, infection , liver disorder, nausea , occult blood, venoocclusive liver disease. Busulfex dosage: 18.4 ML, INTRAVENOUS. During the same period patient was treated with CYCLOPHOSPHAMIDE, PHENYTOIN, TACROLIMUS, METHOTREXATE. Patient recovered.

Busulfex Side Effects Report #5743657-5
Busulfex side effect was reported by a Health Professional from JAPAN on May 08, 2008. Male patient, 60 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: adenoviral haemorrhagic cystitis, anorexia, bone marrow transplant , cytomegalovirus antigen positive, cytomegalovirus viraemia, graft versus host disease, liver disorder, nausea , nystagmus. Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, NEUPOGEN, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5893733-1
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 05, 2008. Female patient, 53 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, anorexia, diarrhoea, hyperglycaemia, klebsiella sepsis, liver disorder, malaise, nausea , pneumonia klebsiella. Busulfex dosage: 27.2 ML, INTRAVENOUS. During the same period patient was treated with CYCLOSPORINE, FLUDARABINE PHOSPHATE, VALPROATE, NARTOGRASTIM, METHOTREXATE, METHYLPREDNISOLONE. Patient died.

Busulfex Side Effects Report #6092953-3
Busulfex side effect was reported by a Consumer or non-health professional from KOREA, REPUBLIC OF on Feb 11, 2009. Female patient, 52 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: chronic graft versus host disease, cytomegalovirus infection , disease progression, disease recurrence, liver disorder, oral disorder, skin disorder, stem cell transplant. Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, THYMOGLOBULIN. Patient recovered.


Busulfex Side Effects Report #6091299-7
Busulfex side effect was reported by a Consumer or non-health professional from KOREA, REPUBLIC OF on Feb 11, 2009. Male patient, 50 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: chronic graft versus host disease, cytomegalovirus infection , disease progression, disease recurrence, liver disorder, skin disorder, stem cell transplant, treatment failure. Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, THYMOGLOBULIN. Patient recovered.

Busulfex Side Effects Report #5809439-0
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on June 27, 2008. Male patient, 47 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anorexia, bone marrow transplant rejection, liver disorder, liver function test abnormal, nausea , platelet count decreased, pneumonia . Busulfex dosage: unknown. During the same period patient was treated with NEUPOGEN, METHOTREXATE, CYCLOSPORINE, FLUDARABINE PHOSPHATE, PHENYTOIN. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5810458-9
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on June 27, 2008. Female patient, 46 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: liver disorder. Busulfex dosage: unknown. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #6092931-4
Busulfex side effect was reported by a Physician from KOREA, REPUBLIC OF on Feb 11, 2009. Male patient, 45 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: chronic graft versus host disease, cytomegalovirus infection , liver disorder, oral disorder, stem cell transplant. Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, THYMOGLOBULIN. Patient recovered.

Busulfex Side Effects Report #5698170-0
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Mar 21, 2008. Female patient, 40 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acinetobacter infection, acute graft versus host disease, anorexia, cystitis haemorrhagic, cytomegalovirus antigen positive, liver disorder, malaise, mucous membrane disorder, nausea . Busulfex dosage: 31.2 ML, INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, METHOTREXATE, ITRACONAZOLE, GANCICLOVIR. Patient was hospitalized and became disabled. Patient recovered.


Busulfex Side Effects Report #5767271-0
Busulfex side effect was reported by a Consumer or non-health professional from FRANCE on May 27, 2008. Male patient, 40 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, blood bilirubin increased, blood lactate dehydrogenase increased, liver disorder, nervous system disorder, platelet count decreased, thrombotic microangiopathy. Busulfex dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, CYCLOSPORINE, METHOTREXATE. Patient died.

Busulfex Side Effects Report #5877265-2
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 25, 2008. Male patient, 35 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia recurrent, enterococcal sepsis, hyperkalaemia, liver disorder, renal failure, stenotrophomonas sepsis, stomatitis, ventricular fibrillation. Busulfex dosage: 34 ML, DAILY DOSE INTRAVENOUS. During the same period patient was treated with CYCLOSPORINE, FLUDARABINE PHOSPHATE, VALPROATE, FILGRASTIM. Patient died on 06/15/2007.

Busulfex Side Effects Report #5979845-2
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Nov 13, 2008. Male patient, 35 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: enterococcal sepsis, hyperkalaemia, liver disorder, renal failure, stenotrophomonas sepsis, stomatitis, ventricular fibrillation. Busulfex dosage: 34 ML, DAILY DOSE, INTRAVENOUS. During the same period patient was treated with CYCLOSPORINE, FLUDARABINE PHOSPHATE, VALPROATE, FILGRASTIM. Patient died.

Busulfex Side Effects Report #6025478-1
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Dec 17, 2008. Male patient, 35 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: enterococcal sepsis, liver disorder, renal failure, stenotrophomonas sepsis, stomatitis, ventricular fibrillation. Busulfex dosage: 34 ML, DAILY DOSE INTRAVENOUS. During the same period patient was treated with CYCLOSPORINE, FLUDARABINE PHOSPHATE, VALPROATE, FILGRASTIM. Patient died on 06/16/2007.

Busulfex Side Effects Report #5832000-9
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on July 16, 2008. Male patient, 31 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, blood lactate dehydrogenase increased, gamma-glutamyltransferase increased, liver disorder. Busulfex dosage: unknown. Patient recovered.


Busulfex Side Effects Report #5877273-1
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Aug 26, 2008. Female patient, child 2 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute myeloid leukaemia recurrent, anorexia, bone marrow transplant , herpes virus infection, liver disorder, malaise, nausea . Busulfex dosage: 9.6 ML, UNK, INTRAVENOUS. During the same period patient was treated with CYCLOPHOSPHAMIDE, VALPROATE, LENOGRASTIM, NARTOGRASTIM, METHOTREXATE. Patient died on 10/07/2007.

Busulfex Side Effects Report #5920078-3
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Sept 29, 2008. Male patient, 16 years of age, was diagnosed with stem cell transplant and was treated with Busulfex. After drug was administered, patient experienced the following side effects: anorexia, bone marrow transplant , diarrhoea, hyperglycaemia, liver disorder, nausea , sepsis , sialoadenitis, stomatitis. Busulfex dosage: unknown. During the same period patient was treated with ALKERAN, VALPROATE, NEUTROGIN, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient recovered.

Busulfex Side Effects Report #5729829-4
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Apr 21, 2008. Female patient, 51 years of age, was treated with Busulfex. After drug was administered, patient experienced the following side effects: acute graft versus host disease, bone marrow transplant rejection, disease recurrence, haemorrhage, herpes virus infection, liver disorder, myelodysplastic syndrome, pneumonia , respiratory disorder. Busulfex dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, VALPROATE, NEUPOGEN, METHOTREXATE, CYCLOSPORINE, WARFARINPOTASSIUM. Patient died.

Busulfex Side Effects Report #5767594-5
Busulfex side effect was reported by a Consumer or non-health professional from ISRAEL on May 27, 2008. Male patient, 34 years of age, was treated with Busulfex. After drug was administered, patient experienced the following side effects: blood bilirubin increased, blood lactate dehydrogenase increased, gastrointestinal disorder, graft versus host disease, liver disorder, nervous system disorder, platelet count decreased, skin disorder, thrombotic microangiopathy. Busulfex dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, METHOTREXATE. Patient died.

Busulfex Side Effects Report #5729831-2
Busulfex side effect was reported by a Consumer or non-health professional from JAPAN on Apr 22, 2008. Male patient, 23 years of age, was treated with Busulfex. After drug was administered, patient experienced the following side effects: bone marrow transplant rejection, convulsion, cytokine storm, diarrhoea, encephalitis viral, engraftment syndrome, graft versus host disease, liver disorder, malaise. Busulfex dosage: 9.4 ML, QID; INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, CYCLOPHOSPHAMIDE, VALPROATE, NARTOGRASTIM, METHOTREXATE, TACROLIMUS. Patient was hospitalized. Patient died.