Clofarabine and bacterial infection Patient Reports February 09, 2010

Clofarabine Side Effects Report #5640763-0
Clofarabine side effect was reported by a Physician from UNITED STATES on Feb 11, 2008. Female patient, 70 years of age, weighting 200.2 lb, was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: aspiration bone marrow abnormal, bacteraemia, bacterial infection , blood culture positive, blood lactate dehydrogenase increased, bronchoalveolar lavage abnormal, bronchoscopy abnormal, candidiasis, cardiomegaly. Clofarabine dosage: 38 MG, QDX5, INTRAVEOUS : 0, QDX5, INTRAVENOUS. During the same period patient was treated with TIGECYCLINE, DIFLUCAN, VANCOMYCIN, VORICONAZOLE, AZITHROMYCIN. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5623282-7
Clofarabine side effect was reported by a Physician from UNITED STATES on Feb 01, 2008. Female patient, 24 years of age, weighting 172.4 lb, was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: asthenia, bacterial infection , cough, diarrhoea, fluid overload, headache , hypotension, hypoxia, neutropenic infection. Clofarabine dosage: 75 MG, QDX5; INTRAVENOUS. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5637705-0
Clofarabine side effect was reported by a Physician from UNITED STATES on Feb 15, 2008. Female patient, 24 years of age, weighting 172.4 lb, was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: acidosis, anaemia, asthenia, bacterial infection , cough, diarrhoea, fatigue, fluid overload, headache . Clofarabine dosage: 75 MG, QDX5, INTRAVENOUS. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5147964-9
Clofarabine side effect was reported by a Physician from UNITED STATES on Oct 25, 2006. Male patient, 23 years of age, weighting 141.0 lb, was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: bacteraemia, bacterial infection , bone disorder, catheter related infection, chills, erythema, fatigue, heart rate increased, inflammation. Clofarabine dosage: 40 MG QD X 5 IV. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient recovered.


Clofarabine Side Effects Report #5194810-3
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Dec 19, 2006. Male patient, 23 years of age, weighting 141.0 lb, was diagnosed with myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: anaemia, aspergillosis, bacteraemia, bacterial infection , catheter related infection, condition aggravated, electrocardiogram t wave abnormal, erythema, febrile neutropenia. Clofarabine dosage: 40 MG QD X 5 IV. During the same period patient was treated with CYTARABINE, COUMADIN, AVELOX. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5509807-0
Clofarabine side effect was reported by a Physician from UNITED STATES on Sept 28, 2007. Male patient, 70 years of age, weighting 194.7 lb, was diagnosed with myelodysplastic syndrome and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: bacterial infection , renal failure. Clofarabine dosage: 20 MG/M2 QD X 5 PO. During the same period patient was treated with BENADRYL, COLACE, MAGNESIUM, OXYCODONE, ZOFRAN, AMBIEN. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5092258-3
Clofarabine side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 15, 2006. Male patient, 59 years of age, was diagnosed with myelodysplastic syndrome and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: bacterial infection , blood culture positive, dialysis , hypotension, lung infiltration, pneumonia , renal failure acute, supraventricular tachycardia. Clofarabine dosage: 40 MG PO. During the same period patient was treated with AMBISOME, VANCOMYCIN. Patient was hospitalized. Patient died on 08/12/2006.

Clofarabine Side Effects Report #5330243-4
Clofarabine side effect was reported by a Physician from UNITED STATES on May 10, 2007. Female patient, 49 years of age, weighting 242.5 lb, was diagnosed with acute myeloid leukaemia recurrent and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: bacterial infection , blood culture positive, cardiac failure, ejection fraction decreased, haemodialysis, hypertension, lung infiltration, multi-organ failure, oxygen consumption increased. Clofarabine dosage: 20 MG/M2 IV. During the same period patient was treated with CYCLOPHOSPHAMIDE, ACETAMINOPHEN, ALLOPURINOL, HYDROCORTISONE. Patient was hospitalized. Patient died on 04/25/2007.

Clofarabine Side Effects Report #5334697-9
Clofarabine side effect was reported by a Physician from UNITED STATES on May 08, 2007. Female patient, child 9 years of age, weighting 52.03 lb, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: atelectasis, bacterial infection , blood pressure decreased, candidiasis, central nervous system infection, cerebral fungal infection, csf test abnormal, culture stool positive. Clofarabine dosage: 27 MG QD X 5 IV. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE, VORICONAZOLE, BACTRIM, POTASSIUM CHLORIDE. Patient was hospitalized. Patient recovered.


Clofarabine Side Effects Report #5345258-X
Clofarabine side effect was reported by a Physician from UNITED STATES on May 18, 2007. Female patient, child 9 years of age, weighting 52.03 lb, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: alpha haemolytic streptococcal infection, atelectasis, bacterial infection , blood pressure decreased, candidiasis, catheter related infection, cerebral fungal infection, csf bacteria identified, fatigue. Clofarabine dosage: 27 MG QD X 5; IV. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE, VORICONAZOLE, BACTRIM, POTASSIUM CHILORIDE. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5088628-X
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Aug 10, 2006. Male patient, 73 years of age, was diagnosed with acute myeloid leukaemia, myelodysplastic syndrome and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: bacterial infection , breath sounds abnormal, confusional state, rales, renal failure acute, respiratory distress. Clofarabine dosage: 71 MG DAILY IV. Patient died on 08/04/2006.

Clofarabine Side Effects Report #5518911-2
Clofarabine side effect was reported by a Physician from UNITED STATES on Nov 06, 2007. Male patient, 73 years of age, weighting 211.0 lb, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: atrial fibrillation , bacterial infection , blood creatine phosphokinase increased, blood creatinine increased, brain abscess, bronchial haemorrhage, candida pneumonia, cardiac failure congestive, continuous haemodiafiltration. Clofarabine dosage: 15 MG QD X 5 IV. During the same period patient was treated with CADUET, METFORMIN, COUMADIN, ACTOS, POTASSIUM GLUCONATE, ASCENSIA MICROFILM STRIPS, LANCETS. Patient died.

Clofarabine Side Effects Report #5526055-9
Clofarabine side effect was reported by a Physician from UNITED STATES on Nov 20, 2007. Male patient, 73 years of age, weighting 211.0 lb, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: atrial fibrillation , bacterial infection , blood creatine phosphokinase increased, blood creatinine increased, bronchial haemorrhage, candida pneumonia, cardiac failure congestive, continuous haemodiafiltration, electrocardiogram abnormal. Clofarabine dosage: 15 MG QD X 5; IV. During the same period patient was treated with CYTARABINE, CADUET, METFORMIN, COUMADIN, ACTOS, POTASSIUM GLUCONATE, ASCENSIA MICROFILM STRIPS, LANCETS. Patient died on 10/14/2007.

Clofarabine Side Effects Report #4741544-2
Clofarabine side effect was reported by a Physician from UNITED KINGDOM on Aug 01, 2005. Female patient, 70 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: acidosis, atrial fibrillation , bacterial infection , chest pain , haemodialysis, hypotension, neutropenic sepsis, renal impairment. Clofarabine dosage: 43 MG QD X 5 IV. During the same period patient was treated with CIPROFLOXACIN, OMEPRAZOLE, ACYCLOVIR, PARACETAMOL, CHLORPHENIRAMINE MALEATE, ONDANSETRON, DEXAMETHASONE, ITRACONAZOLE. Patient was hospitalized. Patient died on 07/31/2005.


Clofarabine Side Effects Report #4961376-X
Clofarabine side effect was reported by a Physician from UNITED KINGDOM on Mar 16, 2006. Female patient, 70 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: acidosis, anaemia, atrial fibrillation , bacterial infection , escherichia infection, haemodialysis, hypotension, neutropenic sepsis. Clofarabine dosage: unknown. During the same period patient was treated with CIPROFLOXACIN, OMEPRAZOLE, ACYCLOVIR, PARACETAMOL, CHLORPHENIRAMINE MALEATE, ONDANSETRON, DEXAMETHASONE. Patient was hospitalized. Patient died on 07/31/2005.

Clofarabine Side Effects Report #5105823-1
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Aug 29, 2006. Male patient, 67 years of age, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: bacterial infection , blood culture positive, febrile neutropenia, hypoxia, pancytopenia, pneumonia , renal failure, respiratory distress, respiratory failure. Clofarabine dosage: 87.2 MG DAILY IV. During the same period patient was treated with CYTARABINE, FLAGYL, NPH INSULIN, ATENOLOL, ALLOPURINOL, FAMVIR, ALTACE, LASIX. Patient died on 07/24/2006.

Clofarabine Side Effects Report #4992281-0
Clofarabine side effect was reported by a Physician from UNITED STATES on Apr 18, 2006. Male patient, 67 years of age, weighting 187.6 lb, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: abdominal tenderness, arthralgia, asthenia, bacterial infection , blood creatinine increased, blood culture positive, bone marrow failure, bone pain, chills. Clofarabine dosage: 47.7 MG IV. During the same period patient was treated with CYSTOSINE ARABINOSIDE, CYSTOSINE ARABINOSIDE, ISOSORBIDE, FLOMAX, LESCOL, SPIRIVA, ADVAIR DISKUS. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5284133-6
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Mar 19, 2007. Male patient, 40 years of age, was diagnosed with acute myeloid leukaemia, myelodysplastic syndrome and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: arthralgia, bacterial infection , blood culture positive, bundle branch block right, chills, electrocardiogram t wave inversion, fatigue, febrile neutropenia, influenza like illness. Clofarabine dosage: unknown. During the same period patient was treated with ACETAMINOPHEN, ALLOPURINOL, HYDROCORTISONE, VORICONAZOLE, CEFEPIME, VANCOMYCIN, VALTREX. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5300255-5
Clofarabine side effect was reported by a Physician from UNITED STATES on Apr 03, 2007. Male patient, 40 years of age, was diagnosed with acute myeloid leukaemia, myelodysplastic syndrome and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: arthralgia, bacterial infection , bundle branch block right, chills, electrocardiogram q waves, fatigue, febrile neutropenia, influenza like illness, lethargy. Clofarabine dosage: unknown. During the same period patient was treated with ACETAMINOPHEN. Patient was hospitalized. Patient recovered.


Clofarabine Side Effects Report #5699297-X
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Mar 31, 2008. Male patient, 32 years of age, weighting 176.4 lb, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: aspiration, bacterial infection , candida serology positive, cerebral haemorrhage, dialysis , diarrhoea, disorientation, escherichia bacteraemia, hyperbilirubinaemia. Clofarabine dosage: 20 MG/M2, QDX5, INTRAVENOUS. During the same period patient was treated with CYTARABINE, ACYCLOVIR. Patient died on 03/27/2008.

Clofarabine Side Effects Report #5632633-9
Clofarabine side effect was reported by a Physician from UNITED STATES on Feb 12, 2008. Female patient, 24 years of age, weighting 172.4 lb, was diagnosed with acute myeloid leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: acidosis, anaemia, asthenia, bacterial infection , blood culture positive, cough, diarrhoea, dyspnoea, fatigue. Clofarabine dosage: 75 MG, QDX5, INTRAVENOUS. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5637702-5
Clofarabine side effect was reported by a Physician from UNITED STATES on Feb 14, 2008. Male patient, 24 years of age, weighting 137.6 lb, was diagnosed with acute myeloid leukaemia, bone marrow conditioning regimen and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: acinetobacter infection, bacterial infection , blood creatinine increased, blood culture positive, convulsion, enterococcal infection, fungal infection , grand mal convulsion, headache . Clofarabine dosage: 40 MG/M2, QD, INTRAVENOUS. During the same period patient was treated with CYTARABINE, THYMOGLOBULIN, PREDNISOLONE ACETATE. Patient was hospitalized. Patient died on 02/13/2008.

Clofarabine Side Effects Report #5599286-X
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Jan 09, 2008. Female patient, child 7 years of age, weighting 77.16 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: aspergillosis, atelectasis, bacterial infection , bone marrow failure, bradycardia, central line infection, convulsion, febrile neutropenia, haematocrit decreased. Clofarabine dosage: 47 MG, QDX5, INTRAVNEOUS. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient died on 01/07/2008.

Clofarabine Side Effects Report #5877444-4
Clofarabine side effect was reported by a Physician from UNITED STATES on Sept 03, 2008. Male patient, 57 years of age, weighting 198.4 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: anaemia, bacterial infection , culture throat positive, culture urine positive, dehydration, escherichia sepsis, febrile neutropenia, hypoxia, multi-organ failure. Clofarabine dosage: 425 MG, QDX5, INTRAVENOUS. During the same period patient was treated with CYTARABINE. Patient died on 05/31/2008.


Clofarabine Side Effects Report #5318433-8
Clofarabine side effect was reported by a Health Professional from UNITED STATES on Apr 17, 2007. Male patient, 19 years of age, weighting 163.6 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: bacterial infection , blood culture positive, blood phosphorus increased, cholelithiasis, epistaxis, fluid imbalance, haematochezia, headache , hyperbilirubinaemia. Clofarabine dosage: 78 MG QD X 5 IV. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE, ALLOPURINOL, AMPHETAMINE AND DEXTROAMPHETAMINE SALTS, DAPSONE, DOCUSATE, ESCITALOPRAM OXALATE, LABETALOL. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5339894-4
Clofarabine side effect was reported by a Physician from UNITED STATES on May 16, 2007. Male patient, 19 years of age, weighting 163.6 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, bacterial infection , blood alkaline phosphatase increased, blood culture positive, bone marrow failure, bronchopulmonary aspergillosis, cholelithiasis, coagulopathy. Clofarabine dosage: 78 MG QD X 5 IV. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE, ALLOPURINOL, AMPHETAMINE AND DEXTROAMPHETAMINE SALTS, DOCUSATE, ESCITALOPRAM OXALATE, LABETALOL, RANITIDINE. Patient was hospitalized. Patient recovered.

Clofarabine Side Effects Report #5921409-0
Clofarabine side effect was reported by a Physician from UNITED STATES on Sept 16, 2008. Male patient, 19 years of age, weighting 165.3 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aplasia, bacterial infection , blood alkaline phosphatase increased, blood bilirubin increased, blood glucose decreased, brain oedema, bronchopulmonary aspergillosis, cardiomegaly. Clofarabine dosage: 78 MG, QDX5, INTRAVENOUS. During the same period patient was treated with ETOPOSIDE, CYCLOPHOSPHAMIDE, ALLOPURINOL, AMPHETAMINE AND DEXTROAMPHETAMINE SALTS, DAPSONE, DOCUSATE, ESCITALOPRAM, LABETALOL. Patient was hospitalized. Patient died on 06/05/2007.

Clofarabine Side Effects Report #5921410-7
Clofarabine side effect was reported by a Physician from UNITED STATES on Oct 08, 2008. Male patient, 19 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Clofarabine. After drug was administered, patient experienced the following side effects: bacterial infection , blood culture positive, multi-organ failure, septic shock. Clofarabine dosage: 52 MG/M2, QDX3, INTRAVENOUS. Patient died on 09/21/2008.

Clofarabine Side Effects Report #4868845-1
Clofarabine side effect was reported by a Physician from SPAIN on Dec 14, 2005. Male patient, child 4 years of age, was treated with Clofarabine. After drug was administered, patient experienced the following side effects: bacterial infection , blood culture positive, bone pain, chills, hepatomegaly, hypoproteinaemia, mucosal inflammation, pyrexia, transaminases increased. Clofarabine dosage: unknown. During the same period patient was treated with CYTARABINE. Patient recovered.