Methotrexate and bone marrow failure Patient Reports February 09, 2010

Methotrexate Side Effects Report #5952923-X
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on Nov 10, 2008. Female patient, child 9 years of age, was diagnosed with stem cell transplant and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, epstein-barr virus associated lymphoproliferative disorder, epstein-barr virus infection, stem cell transplant. Methotrexate dosage: unknown. During the same period patient was treated with ALEMTUZUMAB, CYCLOSPORINE, CYCLOPHOSPHAMIDE, TREOSULFAN. Patient recovered.

Methotrexate Side Effects Report #5353029-3
Methotrexate side effect was reported by a Consumer or non-health professional from CZECH REPUBLIC on May 22, 2007. Female patient, 82 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, febrile neutropenia, pancytopenia. Methotrexate dosage: 10 MG/WEEK, ORAL. Patient died.

Methotrexate Side Effects Report #5375387-6
Methotrexate side effect was reported by a Consumer or non-health professional from CZECH REPUBLIC on June 13, 2007. Female patient, 82 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, bronchopneumonia, febrile neutropenia, pancytopenia. Methotrexate dosage: 10 MG/WEEK ORAL. During the same period patient was treated with MONOSAN, MOLSIHEXAL RETARD, MANINIL, VASOCARDIN, ENAP, LIPANOR, WARFARIN, FURON. Patient died.

Methotrexate Side Effects Report #5995862-0
Methotrexate side effect was reported by a Consumer or non-health professional from on Dec 09, 2008. Female patient, 77 years of age, was diagnosed with rheumatoid arthritis , supportive care and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: blood creatinine increased, bone marrow failure, dehydration, diarrhoea, malaise, pancytopenia, vomiting. Methotrexate dosage: unknown. During the same period patient was treated with FOLINIC ACID, ANTIMICROBIAL TREATMENT. Patient was hospitalized. Patient died.


Methotrexate Side Effects Report #6020711-4
Methotrexate side effect was reported by a Physician from UNITED KINGDOM on Dec 09, 2008. Female patient, 77 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, diarrhoea, renal impairment. Methotrexate dosage: 10MG; 15MG; ONCE WEEKLY. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #6060266-1
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on Jan 19, 2009. Female patient, 77 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, dehydration, diarrhoea, malaise, pancytopenia, renal impairment, vomiting. Methotrexate dosage: 15 MG, ONCE WEEKLY. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #5222677-3
Methotrexate side effect was reported by a Physician from UNITED KINGDOM on Jan 08, 2007. Female patient, 74 years of age, was diagnosed with rheumatoid arthritis , urinary tract infection  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, clostridial infection, contraindication to medical treatment, diarrhoea, fall , haematuria, hip fracture. Methotrexate dosage: unknown. During the same period patient was treated with TRIMETHOPRIM, FOLATE, CIPROFLOXACIN. Patient died on 09/03/2005.

Methotrexate Side Effects Report #4920005-1
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on Feb 03, 2006. Female patient, 72 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: accidental overdose, arteriosclerosis coronary artery, bone marrow failure, cardiac disorder, cardiomegaly, cerebral haemorrhage, fibrosis, immunodeficiency. Methotrexate dosage: 15 MG DAILY. Patient died.

Methotrexate Side Effects Report #4983220-7
Methotrexate side effect was reported by a Physician from GERMANY on Apr 05, 2006. Female patient, 72 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: accidental overdose, arteriosclerosis coronary artery, bone marrow failure, cardiac hypertrophy, cerebral haemorrhage, immunodeficiency, mucosal haemorrhage, myocardial fibrosis. Methotrexate dosage: 15 MG/DAY. During the same period patient was treated with DIGOXIN. Patient was hospitalized. Patient died.


Methotrexate Side Effects Report #5412765-0
Methotrexate side effect was reported by a Consumer or non-health professional from AUSTRALIA on July 03, 2007. Female patient, 61 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: blood albumin decreased, bone marrow failure, cough, diarrhoea, epistaxis, lung consolidation, mouth ulceration, nasal ulcer. Methotrexate dosage: 7.5 MG/WEEK ORAL. During the same period patient was treated with SULFAMETHOXAZOLE AND TRIMETHOPRIM, DICLOFENAC, MYSTECLIN. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5417919-5
Methotrexate side effect was reported by a Consumer or non-health professional from AUSTRALIA on July 25, 2007. Female patient, 61 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bacteria sputum identified, blood albumin decreased, blood creatinine abnormal, blood urea increased, bone marrow failure, cough, diarrhoea, epistaxis. Methotrexate dosage: 7.5 MG/WEEK ORAL. During the same period patient was treated with SULFAMETHOXAZOLE AND TRIMETHOPRIM, DICLOFENAC, MYSTECLIN. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5060624-8
Methotrexate side effect was reported by a Pharmacist from UNITED STATES on July 20, 2006. Female patient was diagnosed with rheumatoid arthritis , staphylococcal infection  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, staphylococcal infection , stomatitis. Methotrexate dosage: 7.5MG Q WEEK PO. During the same period patient was treated with BACTRIM DS. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5054213-9
Methotrexate side effect was reported by a Consumer or non-health professional from on July 03, 2006. Male patient, 70 years of age, was diagnosed with psoriatic arthropathy and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: abdominal discomfort, activated partial thromboplastin time prolonged, ascites, aspartate aminotransferase increased, blood albumin decreased, blood creatinine increased, blood urea increased, bone marrow failure, c-reactive protein increased. Methotrexate dosage: 7.5 TO 15 MG PER WEEK. During the same period patient was treated with FOLATE, MELOXICAM, CARVEDILOL, MODURETICS, AMILORIDE HYDROCHLORIDE, HYDROCHLOROTHIAZIDE, RAMIPRIL, CLOPIDOGREL. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #5200916-2
Methotrexate side effect was reported by a Health Professional from BELGIUM on Jan 02, 2007. Male patient, 66 years of age, was diagnosed with psoriatic arthropathy and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, candidiasis, dermatitis exfoliative, hepatosplenomegaly, hepatotoxicity, mouth ulceration, nausea , pyrexia, stomatitis. Methotrexate dosage: unknown. During the same period patient was treated with FOLIC ACID. Patient was hospitalized. Patient recovered.


Methotrexate Side Effects Report #5205749-9
Methotrexate side effect was reported by a Health Professional from BELGIUM on Jan 09, 2007. Male patient, 66 years of age, was diagnosed with psoriatic arthropathy and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, candidiasis, dermatitis exfoliative, hepatosplenomegaly, hepatotoxicity, mouth ulceration, nausea , pyrexia, stomatitis. Methotrexate dosage: unknown. During the same period patient was treated with FOLIC ACID. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5412768-6
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on July 24, 2007. Female patient, 16 years of age, was diagnosed with psoriatic arthropathy and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: blood immunoglobulin g decreased, bone marrow failure, epistaxis, heart rate increased, hypogammaglobulinaemia, mouth ulceration, pancytopenia. Methotrexate dosage: 5-10MG WEEKLY ORAL. During the same period patient was treated with IBUPROFEN, PREDNISOLONE. Patient recovered.

Methotrexate Side Effects Report #6123477-2
Methotrexate side effect was reported by a Consumer or non-health professional from on Mar 16, 2009. Male patient, 57 years of age, was diagnosed with psoriasis, bone marrow failure, wound treatment and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, skin ulcer, staphylococcal sepsis. Methotrexate dosage: unknown. During the same period patient was treated with LEUCOVORIN CALCIUM, LEUCOVORIN CALCIUM, FILGRASTIM, PLATELETS, ANTIBIOTICS, ANTIFUNGAL, POVIDONE IODINE. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #6003111-2
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on Dec 02, 2008. Female patient, child 8 years of age, was diagnosed with prophylaxis against graft versus host disease, immunosuppression and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, epstein-barr virus associated lymphoproliferative disorder. Methotrexate dosage: unknown. During the same period patient was treated with ALEMTUZUMAB, CYCLOSPORINE, CYCLOPHOSPHAMIDE, TREOSULFAN. Patient recovered.

Methotrexate Side Effects Report #6138950-0
Methotrexate side effect was reported by a Physician from UNITED STATES on Mar 18, 2009. Female patient, 65 years of age, was diagnosed with polymyositis and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, central nervous system lymphoma, epstein-barr virus infection, erythropoiesis abnormal, pancytopenia, respiratory disorder. Methotrexate dosage: unknown. During the same period patient was treated with PREDNISONE, AZATHIOPRINE, CYCLOPHOSPHAMIDE. Patient died on 10/05/2006.


Methotrexate Side Effects Report #5278390-X
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on Mar 06, 2007. Male patient, 68 years of age, was diagnosed with non-hodgkin's lymphoma, pneumonia  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, renal impairment, stomatitis. Methotrexate dosage: 2800 MG FREQ UNK IV. During the same period patient was treated with ERTAPENEM, EPIRUBICIN, ETOPOSIDE, FOLINIC ACID, IFOSFAMIDE, MESNA, OMEPRAZOLE. Patient recovered.

Methotrexate Side Effects Report #5907749-X
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on Sept 15, 2008. Female patient, child 3. years of age, was diagnosed with medulloblastoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, ascites, blood bilirubin increased, bone marrow failure, hepatomegaly, hepatotoxicity, mucosal inflammation, prothrombin time prolonged. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, CISPLATIN, ETOPOSIDE, CYCLOPHOSPHAMIDE, TEMOZOLOMIDE, GLUCARPIDASE. Patient recovered.

Methotrexate Side Effects Report #5917090-7
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on Sept 29, 2008. Female patient, child 3. years of age, was diagnosed with medulloblastoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: ascites, bone marrow failure, hepatomegaly, hepatotoxicity, mucosal inflammation, prothrombin time prolonged, renal failure acute, vomiting. Methotrexate dosage: 400 MG/KG (9 G/M2), 200 MG. During the same period patient was treated with VINCRISTINE, CISPLATIN, ETOPOSIDE, CYCLOPHOSPHAMIDE, TEMOZOLOMIDE. Patient recovered.

Methotrexate Side Effects Report #5711160-4
Methotrexate side effect was reported by a Physician from UNITED KINGDOM on Apr 04, 2008. Female patient, child 3 years of age, was diagnosed with medulloblastoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, ascites, blood bilirubin increased, bone marrow failure, febrile neutropenia, hepatomegaly, mucosal inflammation. Methotrexate dosage: 400 MG/KG PER_CYCLE. During the same period patient was treated with VINCRISTINE, CISPLATIN, FLUCONAZOLE, ETOPOSIDE, CYCLOPHOSPHAMIDE, TEMOZOLOMIDE, PARENTERAL. Patient recovered.

Methotrexate Side Effects Report #5866616-0
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED KINGDOM on Aug 11, 2008. Female patient, child 3 years of age, was diagnosed with medulloblastoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, ascites, blood bilirubin increased, bone marrow failure, hepatomegaly, mucosal inflammation. Methotrexate dosage: 400 MG/KG. During the same period patient was treated with CISPLATIN, CYCLOPHOSPHAMIDE, ETOPOSIDE, TEMOZOLOMIDE, VINCRISTINE SULPHATE. Patient recovered.


Methotrexate Side Effects Report #5216875-2
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 08, 2007. Female patient, 32 years of age, was diagnosed with ectopic pregnancy and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: abdominal pain lower, bone marrow failure, thrombocytopenia, uterine enlargement, uterine haemorrhage. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #5101951-5
Methotrexate side effect was reported by a Physician from UNITED STATES on Aug 28, 2006. Female patient, 22 years of age, weighting 110.0 lb, was diagnosed with ectopic pregnancy and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, bone marrow failure, diarrhoea haemorrhagic, lung injury, mucosal inflammation, multi-organ disorder, oral pain, transaminases increased. Methotrexate dosage: 50 MG/M2 ONCE IM. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #6035090-6
Methotrexate side effect was reported by a Consumer or non-health professional from on Jan 07, 2009. Male patient, 58 years of age, was diagnosed with central nervous system lymphoma, evidence based treatment and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, mucosal inflammation, pyrexia, renal failure acute, sepsis . Methotrexate dosage: unknown. During the same period patient was treated with PIPERACILLIN AND TAZOBACTAM, CPDG, CHARCOAL HAEMOPERFUSION, LEUCOVORIN CALCIUM. Patient died.

Methotrexate Side Effects Report #6055788-3
Methotrexate side effect was reported by a Physician from SPAIN on Jan 12, 2009. Male patient, 58 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, dialysis , mucosal inflammation, renal failure acute, sepsis . Methotrexate dosage: unknown. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #6115463-3
Methotrexate side effect was reported by a Physician from SPAIN on Mar 06, 2009. Male patient, 58 years of age, was diagnosed with central nervous system lymphoma, pyrexia, evidence based treatment and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, mucosal inflammation, pyrexia, renal failure acute, sepsis . Methotrexate dosage: unknown. During the same period patient was treated with PIPERACILLIN AND TAZOBACTAM, PIPERACILLIN AND TAZOBACTAM, LEUCOVORIN CALCIUM. Patient was hospitalized. Patient died.


Methotrexate Side Effects Report #6120626-7
Methotrexate side effect was reported by a Physician from SPAIN on Mar 06, 2009. Male patient, 58 years of age, was diagnosed with central nervous system lymphoma, pyrexia, evidence based treatment and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, mucosal inflammation, pyrexia, renal failure acute, sepsis . Methotrexate dosage: unknown. During the same period patient was treated with PIPERACILLIN AND TAZOBACTAM, PIPERACILLIN AND TAZOBACTAM, LEUCOVORIN CALCIUM. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #6120701-7
Methotrexate side effect was reported by a Physician from SPAIN on Mar 06, 2009. Male patient, 58 years of age, was diagnosed with central nervous system lymphoma, pyrexia, evidence based treatment and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, mucosal inflammation, pyrexia, renal failure acute, sepsis . Methotrexate dosage: unknown. During the same period patient was treated with PIPERACILLIN AND TAZOBACTAM, PIPERACILLIN AND TAZOBACTAM, LEUCOVORIN CALCIUM. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #5412063-5
Methotrexate side effect was reported by a Physician from UNITED STATES on July 30, 2007. Male patient, child 8 years of age, was diagnosed with burkitt's lymphoma stage iii, computerised tomogram and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, contrast media reaction, encephalitis , grand mal convulsion, hypertension, mucosal inflammation. Methotrexate dosage: unknown. During the same period patient was treated with RADIOGRAPHIC CONTRAST, CYCLOPHOSPHAMIDE, VINCRISTINE, PREDNISONE, DOXORUBICIN HYDROCHLORIDE. Patient recovered.

Methotrexate Side Effects Report #5264574-3
Methotrexate side effect was reported by a Health Professional from FRANCE on Mar 12, 2007. Female patient, 16 years of age, was diagnosed with bone sarcoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, hepatotoxicity, mucosal inflammation, nephropathy toxic, pyrexia, reversible posterior leukoencephalopathy syndrome. Methotrexate dosage: unknown. During the same period patient was treated with ETOPOSIDE, IFOSFAMIDE, FOLINIC ACID. Patient recovered.

Methotrexate Side Effects Report #5270993-1
Methotrexate side effect was reported by a Health Professional from FRANCE on Mar 19, 2007. Female patient, 16 years of age, weighting 110.2 lb, was diagnosed with bone sarcoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, haemodialysis, hepatotoxicity, mucosal inflammation, nephropathy toxic, pyrexia, reversible posterior leukoencephalopathy syndrome. Methotrexate dosage: unknown. During the same period patient was treated with ETOPOSIDE, IFOSFAMIDE, FOLINIC ACID. Patient recovered.


Methotrexate Side Effects Report #5412064-7
Methotrexate side effect was reported by a Physician from UNITED STATES on July 30, 2007. Female patient, 14 years of age, was diagnosed with bone sarcoma, computerised tomogram and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: abdominal mass, bone marrow failure, hepatic enzyme increased, hepatotoxicity, herpes simplex , hypertension, hypotension. Methotrexate dosage: unknown. During the same period patient was treated with RADIOGRAPHIC CONTRAST, CISPLATIN, DOXORUBICIN. Patient recovered.

Methotrexate Side Effects Report #4938449-0
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 08, 2006. Female patient, weighting 179.2 lb, was diagnosed with b precursor type acute leukaemia, precursor b-lymphoblastic lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: blood bilirubin increased, bone marrow failure, dialysis , enterococcal sepsis, fungal sepsis, hypotension, metabolic acidosis, multi-organ failure. Methotrexate dosage: 60 MG. During the same period patient was treated with DOXORUBICIN, DEXAMETHASONE, CYTARABINE, CYCLOPHOSPHAMIDE. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #5374155-9
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on June 19, 2007. Female patient, 75 years of age, was diagnosed with arthropathy, rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, bone marrow toxicity, glossitis, odynophagia, oral mucosal petechiae, pancytopenia, pneumonia , sepsis . Methotrexate dosage: 15 MG WEEKLY;. During the same period patient was treated with AMINOGLYCOSIDE. Patient died.

Methotrexate Side Effects Report #5239604-5
Methotrexate side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Jan 27, 2007. Female patient, 33 years of age, was diagnosed with arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: asthenia, bone marrow failure, chest discomfort, leukaemoid reaction, mucosal inflammation, no therapeutic response, oedema peripheral, respiratory distress, tachycardia. Methotrexate dosage: 5 MG WEEKLY. During the same period patient was treated with FOLIC ACID, PREDNISOLONE. Patient recovered.

Methotrexate Side Effects Report #5590849-4
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on Jan 02, 2008. Male patient, 75 years of age, was diagnosed with ankylosing spondylitis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: blood creatinine increased, bone marrow failure, skin toxicity, toxic epidermal necrolysis. Methotrexate dosage: 15 MG (DAY 1), 25 MG (DAY 2) INTRAVENOUS; INTRAVENOUS. During the same period patient was treated with BISOPROLOL FUMARATE, LISINOPRIL, OXYCODON. Patient recovered.


Methotrexate Side Effects Report #5413317-9
Methotrexate side effect was reported by a Physician from UNITED STATES on July 30, 2007. Female patient, 17 years of age, was diagnosed with acute lymphocytic leukaemia, migraine  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, mucosal inflammation, nausea , pyrexia, rash , renal failure acute. Methotrexate dosage: 100 MG/M2 IV. During the same period patient was treated with ZOMIG. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5475134-3
Methotrexate side effect was reported by a Consumer or non-health professional from on Sept 25, 2007. Female patient, 17 years of age, was diagnosed with acute lymphocytic leukaemia, migraine  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood urea increased, bone marrow failure, mucosal inflammation, nausea , pyrexia, rash . Methotrexate dosage: unknown. During the same period patient was treated with ZOLMITRIPTAN, LEUCOVORIN CALCIUM. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5582974-9
Methotrexate side effect was reported by a Physician from GERMANY on Dec 20, 2007. Male patient, 17 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: abdominal pain , acute respiratory distress syndrome, anaemia, aspergillosis, blood culture positive, bone marrow failure, bronchial ulceration, disease progression, febrile neutropenia. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, DAUNORUBICIN, ASPARAGINASE, DEXAMETHASONE, PREDNISONE. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #5215816-1
Methotrexate side effect was reported by a Consumer or non-health professional from FINLAND on Jan 19, 2007. Female patient, 14 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, gait disturbance, guillain-barre syndrome , neurogenic bladder, osteonecrosis , paraplegia, protein total decreased. Methotrexate dosage: unknown. During the same period patient was treated with CYTARABINE, PREDNISOLONE, PREDNISONE. Patient recovered.

Methotrexate Side Effects Report #5500074-0
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on Oct 09, 2007. Female patient, 14 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood brain barrier defect, blood immunoglobulin a decreased, bone marrow failure, guillain-barre syndrome , leukaemia recurrent, neurogenic bladder, neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with CYTARABINE, PREDNISOLONE. Patient was hospitalized and became disabled. Patient died.

Methotrexate Side Effects Report #5643530-7
Methotrexate side effect was reported by a Consumer or non-health professional from on Feb 25, 2008. Female patient, child 1 years of age, was diagnosed with acute lymphocytic leukaemia, prophylaxis and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: blood creatinine increased, bone marrow failure, creatinine renal clearance decreased, mucosal inflammation, renal failure acute. Methotrexate dosage: unknown. During the same period patient was treated with LEUCOVORIN CALCIUM, MERCAPTOPURINE. Patient recovered.

Methotrexate Side Effects Report #4889595-1
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 20, 2006. Female patient, weighting 242.0 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, diarrhoea, febrile neutropenia, nasal congestion, thrombocytopenia, vomiting. Methotrexate dosage: unknown. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5047261-6
Methotrexate side effect was reported by a Consumer or non-health professional from FRANCE on June 19, 2006. Female patient, 49 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: aphasia , aplasia, bone marrow failure, brain oedema, candida sepsis, cerebral haematoma, cerebral haemorrhage, enterobacter sepsis. Methotrexate dosage: unknown. During the same period patient was treated with DOXORUBICIN, VINCRISTINE, MABTHERA, ETOPOSIDE, CYCLOPHOSPHAMIDE, CYTARABINE. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #5228751-X
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on Jan 19, 2007. Female patient, 14 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, arthralgia, aspartate aminotransferase increased, asthenia, atonic urinary bladder, blood immunoglobulin a decreased, blood immunoglobulin m decreased, bone marrow failure, gait disturbance. Methotrexate dosage: 12 MG PER_CYCLE IT. During the same period patient was treated with CYTARABINE, PREDNISOLONE, IBUPROFEN. Patient recovered.

Methotrexate Side Effects Report #5243086-7
Methotrexate side effect was reported by a Consumer or non-health professional from on Feb 14, 2007. Female patient, 14 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: areflexia, blood albumin decreased, blood brain barrier defect, blood immunoglobulin a decreased, blood immunoglobulin m decreased, bone marrow failure, demyelination, gait disturbance, hepatic enzyme increased. Methotrexate dosage: unknown. During the same period patient was treated with PREDNISONE. Patient died.


Methotrexate Side Effects Report #5631833-1
Methotrexate side effect was reported by a Physician from FRANCE on Feb 18, 2008. Male patient was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, dermatitis exfoliative, renal tubular necrosis, stomatitis. Methotrexate dosage: unknown. During the same period patient was treated with GLEEVEC. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #5634555-6
Methotrexate side effect was reported by a Physician from FRANCE on Feb 18, 2008. Male patient was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bone marrow failure, dermatitis exfoliative, renal tubular necrosis, stomatitis. Methotrexate dosage: unknown. During the same period patient was treated with GLEEVEC. Patient was hospitalized. Patient died.