Myozyme and cardiac failure 
Myozyme and cardiac failure Patient Reports February 09, 2010
Myozyme Side Effects Report #5859264-X
Myozyme side effect was reported by a Health Professional from NETHERLANDS on Aug 15, 2008. Male patient, 77 years of age, weighting 156.5 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, decubitus ulcer, myocardial infarction, respiratory failure. Myozyme dosage: 20 MG/KG, QOW, INTRAVENOUS. Patient was hospitalized. Patient died on 08/09/2008.
Myozyme Side Effects Report #5873523-6
Myozyme side effect was reported by a Physician from NETHERLANDS on Aug 15, 2008. Male patient, 77 years of age, weighting 156.5 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, decubitus ulcer, myocardial infarction, respiratory failure. Myozyme dosage: 20 MG/KG, QOW, INTRAVENOUS. Patient was hospitalized. Patient died on 08/09/2008.
Myozyme Side Effects Report #5388748-6
Myozyme side effect was reported by a Physician from UNITED STATES on June 28, 2007. Male patient, 66 years of age, weighting 165.3 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: back pain
, cardiac failure, convulsion, hypotension, mental status changes, osteomyelitis, pneumonia , renal failure, unresponsive to stimuli. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient was hospitalized. Patient died on 06/29/2007.Myozyme Side Effects Report #5994141-5
Myozyme side effect was reported by a Health Professional from UNITED KINGDOM on Nov 21, 2008. Female patient, 43 years of age, weighting 105.8 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, blood pressure decreased, bronchiectasis, cardiac failure, condition aggravated, lung abscess, no therapeutic response, pneumonia
, renal failure. Myozyme dosage: 20 MG/KG, Q2W; INTRAVENOUS. During the same period patient was treated with PEPPERMINT WATER. Patient died on 07/28/2008.Myozyme Side Effects Report #5692867-4
Myozyme side effect was reported by a Physician from ITALY on Mar 19, 2008. Male patient, 39 years of age, weighting 94.80 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, haemothorax, pneumothorax, pyrexia, respiratory failure, sepsis
. Myozyme dosage: 20 MG/KG, INTRAVENOUS. During the same period patient was treated with ANTIBIOTICS. Patient died on 12/06/2007.Myozyme Side Effects Report #5942803-8
Myozyme side effect was reported by a Physician from UNITED STATES on Oct 22, 2008. Male patient, child 3 years of age, weighting 44.09 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: c-reactive protein increased, cardiac failure, cardiomegaly, dehydration, disease progression, fluid overload, hypoxic encephalopathy, leukocytosis, mental status changes. Myozyme dosage: 20 MG/KG, Q2W; INTRAVENOUS; 40 MG/KG, Q2W; INTRAVENOUS. Patient was hospitalized. Patient died on 10/24/2008.
Myozyme Side Effects Report #5995082-X
Myozyme side effect was reported by a Physician from BRAZIL on Dec 03, 2008. Female patient, child 3 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, choking
, cough, hypotension, influenza, infusion related reaction, pyrexia, viral infection . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5455028-X
Myozyme side effect was reported by a Physician from CHINA on Aug 30, 2007. Female patient, child 2 years of age, weighting 13.87 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, condition aggravated, disease recurrence, muscular weakness, myocardial ischaemia, no therapeutic response, nodal arrhythmia, pneumonia
, ventricular extrasystoles. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.Myozyme Side Effects Report #5474817-9
Myozyme side effect was reported by a Physician from CHINA on Sept 13, 2007. Female patient, child 2 years of age, weighting 13.23 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acinetobacter infection, alpha haemolytic streptococcal infection, aspiration tracheal abnormal, blood creatinine increased, blood sodium decreased, cardiac failure, disease recurrence, electrolyte imbalance, fluid retention. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with MILRINONE. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #5512664-X
Myozyme side effect was reported by a Physician from CHINA on Oct 22, 2007. Female patient, child 2 years of age, weighting 13.87 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acinetobacter infection, alpha haemolytic streptococcal infection, blood immunoglobulin g increased, blood sodium decreased, cardiac failure, condition aggravated, electrolyte imbalance, fluid retention, gene mutation identification test positive. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with MILRINONE. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #5383594-1
Myozyme side effect was reported by a Physician from TURKEY on June 27, 2007. Female patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, cardio-respiratory arrest. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient died on 06/23/2007.
Myozyme Side Effects Report #5454998-3
Myozyme side effect was reported by a Physician from CHINA on Aug 30, 2007. Female patient, child 1 years of age, weighting 13.87 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure decreased, cardiac failure, condition aggravated, cyanosis, disease recurrence, fluid overload, hyperhidrosis, myocardial ischaemia, nodal arrhythmia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with CAPTOPRIL, FRUSEMIDE. Patient recovered.
Myozyme Side Effects Report #5209130-8
Myozyme side effect was reported by a Physician from BRAZIL on Dec 28, 2006. Female patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: areflexia, atelectasis, blood calcium increased, blood glucose increased, blood lactic acid increased, blood potassium decreased, cardiac failure, cardio-respiratory arrest. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient recovered.
Myozyme Side Effects Report #5216726-6
Myozyme side effect was reported by a Physician from GREECE on Jan 04, 2007. Female patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal infection, acute respiratory failure, alanine aminotransferase increased, antibody test positive, asthenia, cardiac failure, cardiac failure acute, cardiac index increased, cardiopulmonary failure. Myozyme dosage: 20 MG/KG QWK IV. During the same period patient was treated with ALPHA, HCL THIAZIDE, SPIRONOLACTONE, DIGITALIS, ENALAPRIL MALEATE. Patient was hospitalized. Patient died on 12/29/2006.
Myozyme Side Effects Report #5236957-9
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 26, 2007. Female patient, weighting 26.01 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, international normalised ratio increased, prothrombin time prolonged, respiratory distress, shock, urine output decreased, urticaria. Myozyme dosage: 250 MG Q2WKS IV. During the same period patient was treated with PULMICORT, CAPTOPRIL, CARVEDILOL, DIGOXIN, LASIX. Patient was hospitalized. Patient died on 02/03/2007.
Myozyme Side Effects Report #5254709-0
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 12, 2007. Female patient, weighting 21.16 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, cardiac failure, condition aggravated, respiratory failure, urinary tract infection
. Myozyme dosage: 200 MG Q2WKS IV. During the same period patient was treated with LASIX, CAPTOPRIL, COREG. Patient was hospitalized. Patient died on 02/15/2007.Myozyme Side Effects Report #5298945-6
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 28, 2007. Female patient, weighting 21.16 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac failure, cardio-respiratory arrest, pneumonia
, respiratory failure, urinary tract infection . Myozyme dosage: 200 MG Q2WKS IV. During the same period patient was treated with LASIX, CAPTOPRIL, COREG. Patient was hospitalized. Patient died on 02/15/2007.Myozyme Side Effects Report #5299727-1
Myozyme side effect was reported by a Physician from ARGENTINA on Mar 27, 2007. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, culture positive, pneumonia
, pseudomonas infection, respiratory distress, sepsis . Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with MEROPENIN, FUROSEMIDE, AMIKACIN, DOPAMINE, MILRINONE, POTASSIUM CHLORIDE, CALCIUM CHLORIDE. Patient was hospitalized. Patient died on 03/28/2007.Myozyme Side Effects Report #5331395-2
Myozyme side effect was reported by a Physician from UNITED STATES on May 02, 2007. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: adhesion
, angiopathy, cardiac failure, collapse of lung, disease progression, effusion, emphysema, granulomatous liver disease. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient died on 03/06/2007.Myozyme Side Effects Report #5097561-9
Myozyme side effect was reported by a Consumer or non-health professional from BRAZIL on Aug 21, 2006. Female patient, weighting 15.43 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood creatine phosphokinase increased, blood lactate dehydrogenase increased, cardiac disorder, cardiac failure, catheter related infection, decreased appetite. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with FUROSEMIDE, CAPTOPRIL, DIGOXIN, COENZYME Q. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #5148156-X
Myozyme side effect was reported by a Physician from BRAZIL on Oct 23, 2006. Male patient, weighting 16.53 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac arrest
, cardiac failure, condition aggravated, heart rate increased, pneumonia , respiratory rate increased, shock, ventricular fibrillation. Myozyme dosage: 20 MG/KG ONCE IV. During the same period patient was treated with CAPTOPRIL, FUROSEMIDE. Patient died on 10/23/2006.Myozyme Side Effects Report #5199501-0
Myozyme side effect was reported by a Physician from BRAZIL on Dec 15, 2006. Female patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: areflexia, atelectasis, blood calcium decreased, blood glucose increased, blood ph increased, blood potassium decreased, cardiac failure, cardio-respiratory arrest, clonic convulsion. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.
Myozyme Side Effects Report #5407344-5
Myozyme side effect was reported by a Physician from UNITED KINGDOM on July 19, 2007. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient died on 07/06/2007.
Myozyme Side Effects Report #5484870-4
Myozyme side effect was reported by a Physician from FRANCE on Sept 26, 2007. Male patient, weighting 26.46 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anoxia, aspiration, bronchial secretion retention, cardiac failure, cardio-respiratory arrest, catheter related infection, convulsion, hypotonia, lung infection. Myozyme dosage: 30 MG/KG Q2WKS IV. During the same period patient was treated with RENITEC, FORTUM, PHOSPHONEUROS. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #5556366-2
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 27, 2007. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, catheter sepsis, cerebral ischaemia, condition aggravated, dehydration, diarrhoea, disease recurrence, disseminated intravascular coagulation, feeding disorder. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient was hospitalized. Patient died on 11/29/2007.
Myozyme Side Effects Report #5622249-2
Myozyme side effect was reported by a Physician from GERMANY on Jan 23, 2008. Female patient, weighting 13.01 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, pneumonia
, pyelonephritis, tachycardia. Myozyme dosage: unknown. During the same period patient was treated with CAPTOPRIL. Patient died on 01/06/2008.Myozyme Side Effects Report #5657647-4
Myozyme side effect was reported by a Physician from GERMANY on Feb 19, 2008. Female patient, weighting 13.01 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac arrest
, cardiac failure, cardiomegaly, oedema, pneumonia , procedural complication, pyelonephritis, tachycardia, ventricular hypertrophy. Myozyme dosage: unknown. During the same period patient was treated with CAPTOPRIL. Patient was hospitalized. Patient died on 01/06/2008.Myozyme Side Effects Report #5689669-1
Myozyme side effect was reported by a Physician from SPAIN on Mar 13, 2008. Male patient, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, bronchospasm, cardiac failure, cyanosis, infusion related reaction, nasopharyngitis, respiratory arrest, respiratory failure, transaminases increased. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS; 40 MG/KG, Q2W, INTRAVENOUS; 20 MG/KG, Q2W, INTRAVENOUS. Patient died on 02/01/2008.
Myozyme Side Effects Report #5746819-6
Myozyme side effect was reported by a Physician from UNITED ARAB EMIRATES on May 04, 2008. Male patient, weighting 10.80 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood creatine phosphokinase increased, cardiac failure, cardio-respiratory arrest, disease progression, hypertrophic cardiomyopathy, hypotonia. Myozyme dosage: 20 MG/KG, Q2W. During the same period patient was treated with PROPRANOLOL. Patient died on 04/14/2008.
Myozyme Side Effects Report #5753736-4
Myozyme side effect was reported by a Physician from SPAIN on May 13, 2008. Female patient, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, cardiac failure, respiratory arrest, respiratory failure. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS; 40 MG/KG,Q2W, INTRAVENOUS. Patient died on 02/01/2008.
Myozyme Side Effects Report #5759052-9
Myozyme side effect was reported by a Physician from SPAIN on Mar 13, 2008. Male patient, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, cardiac failure, infusion related reaction, nasopharyngitis, respiratory arrest, respiratory failure, respiratory tract infection. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS; 40 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ACTOCORTINA, SPIRONOLACTONE, CARVEDILOL. Patient died on 02/01/2008.
Myozyme Side Effects Report #5871196-X
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Aug 15, 2008. Male patient, weighting 13.23 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac arrest
, cardiac failure, condition aggravated, culture urine positive, hypertrophic cardiomyopathy, hypotonia, hypoxia, oxygen consumption increased, pyrexia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient died on 05/15/2006.Myozyme Side Effects Report #5885628-4
Myozyme side effect was reported by a Physician from CHINA on Sept 08, 2008. Female patient, weighting 13.89 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acinetobacter infection, alpha haemolytic streptococcal infection, aspiration tracheal abnormal, blood immunoglobulin g increased, blood sodium decreased, cardiac arrest
, cardiac failure, condition aggravated, disease recurrence. Myozyme dosage: 20 MG/KG, Q2W; INTRAVENOUS. During the same period patient was treated with MILRINONE. Patient was hospitalized. Patient died on 09/06/2008.Myozyme Side Effects Report #5917212-8
Myozyme side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 26, 2008. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, cough, disease progression, hypoxia, irritability, nasopharyngitis, oxygen saturation decreased, rales. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #5927324-0
Myozyme side effect was reported by a Consumer or non-health professional from TURKEY on Oct 10, 2008. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, respiratory tract infection. Myozyme dosage: 20 MG/KG, Q2W. Patient was hospitalized. Patient died.
Myozyme Side Effects Report #5927527-5
Myozyme side effect was reported by a Physician from UNITED STATES on Oct 07, 2008. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, disease progression, nasopharyngitis, refusal of treatment by relative, respiratory failure. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient died on 10/07/2008.
Myozyme Side Effects Report #6060120-5
Myozyme side effect was reported by a Physician from UNITED ARAB EMIRATES on Jan 15, 2009. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspartate aminotransferase increased, blood creatine phosphokinase increased, blood lactate dehydrogenase increased, cardiac failure, hypotension, respiratory distress. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #6070363-2
Myozyme side effect was reported by a Physician from UNITED ARAB EMIRATES on Jan 28, 2009. Male patient, weighting 5.95 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase decreased, aspartate aminotransferase increased, blood creatine phosphokinase increased, blood lactate dehydrogenase increased, cardiac failure, dilatation ventricular, enzyme abnormality, hypotension, respiratory distress. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.