Myozyme and hypotension Patient Reports February 10, 2010

Myozyme Side Effects Report #5940267-1
Myozyme side effect was reported by a Physician from FRANCE on Oct 21, 2008. Female patient, 73 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, bradycardia, bronchitis , cough, cyanosis, dysphagia, electrocardiogram abnormal, hypotension, tachypnoea. Myozyme dosage: unknown. During the same period patient was treated with TAMSULOSIN. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6060121-7
Myozyme side effect was reported by a Physician from FRANCE on Jan 15, 2009. Female patient, 73 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, acute respiratory failure, bradycardia, bronchitis , disease complication, dysphagia, heart sounds abnormal, hypotension. Myozyme dosage: unknown. During the same period patient was treated with TAMSULOSIN, AUGMENTIN, ANTIBIOTICS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5388748-6
Myozyme side effect was reported by a Physician from UNITED STATES on June 28, 2007. Male patient, 66 years of age, weighting 165.3 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: back pain , cardiac failure, convulsion, hypotension, mental status changes, osteomyelitis, pneumonia , renal failure, unresponsive to stimuli. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient was hospitalized. Patient died on 06/29/2007.

Myozyme Side Effects Report #5501335-1
Myozyme side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 15, 2007. Female patient, 62 years of age, weighting 170.9 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: diastolic dysfunction, hypotension. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5401311-3
Myozyme side effect was reported by a Physician from UNITED STATES on July 11, 2007. Female patient, 61 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii, infusion related reaction, prophylaxis and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , blood immunoglobulin g increased, bradycardia, chills, hypotension, hypothermia , infusion related reaction, myocardial infarction, pallor. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with EPINEPHRINE, EVISTA, CALTRATE, ALPHAGAN, CENTRUM, ADVIL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5752263-8
Myozyme side effect was reported by a Physician from UNITED STATES on May 14, 2008. Female patient, 61 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii, infusion related reaction and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , bradycardia, chills, hypersensitivity, hypotension, hypothermia , infusion related reaction, myocardial infarction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with EPINEPHRINE, EVISTA, CALTRATE, ALPHAGAN, CENTRUM, ADVIL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5766642-6
Myozyme side effect was reported by a Physician from UNITED STATES on May 27, 2008. Female patient, 61 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii, infusion related reaction and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , bradycardia, chills, hypersensitivity, hypotension, hypothermia , myocardial infarction, pallor. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with EPINEPHRINE, EVISTA, CALTRATE, ALPHAGAN, CENTRUM, ADVIL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5319722-3
Myozyme side effect was reported by a Physician from GERMANY on Apr 18, 2007. Female patient, 51 years of age, weighting 158.7 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: hypersensitivity, hypotension, infusion related reaction. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ENTHYROX. Patient recovered.

Myozyme Side Effects Report #5154555-2
Myozyme side effect was reported by a Consumer or non-health professional from FRANCE on Oct 31, 2006. Female patient, 44 years of age, weighting 123.5 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: back pain , blood pressure decreased, chest pain , erythema, face oedema, flushing, hypotension. Myozyme dosage: unknown. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5935025-8
Myozyme side effect was reported by a Health Professional from UNITED KINGDOM on Oct 20, 2008. Female patient, 33 years of age, weighting 112.9 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: dizziness , fall , heart rate decreased, hypotension, infusion related reaction, pallor, syncope. Myozyme dosage: 1000 MG/DAY, Q2W, INTRAVENOUS. During the same period patient was treated with CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN. Patient recovered.

Myozyme Side Effects Report #6005617-9
Myozyme side effect was reported by a Health Professional from UNITED KINGDOM on Dec 08, 2008. Female patient, 33 years of age, weighting 112.9 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure increased, dizziness , dyspnoea, feeling hot, flushing, heart rate decreased, heart rate increased, hypotension, immunology test abnormal. Myozyme dosage: 1000 MG/DAY, Q2W, INTRAVENOUS. During the same period patient was treated with CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN. Patient recovered.

Myozyme Side Effects Report #5995082-X
Myozyme side effect was reported by a Physician from BRAZIL on Dec 03, 2008. Female patient, child 3 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, choking , cough, hypotension, influenza, infusion related reaction, pyrexia, viral infection . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5694194-8
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Mar 20, 2008. Female patient, child 2 years of age, weighting 24.25 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bradycardia, hypertrophic cardiomyopathy, hypotension, impaired gastric emptying, ischaemia, oesophageal obstruction, pyloric stenosis, staphylococcal infection . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5718873-9
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Apr 09, 2008. Female patient, child 2 years of age, weighting 24.25 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bradycardia, hypertrophic cardiomyopathy, hypotension, ill-defined disorder, impaired gastric emptying, myocardial ischaemia, nausea , oesophageal disorder. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5935024-6
Myozyme side effect was reported by a Physician from ISRAEL on Oct 15, 2008. Male patient, child 2 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac hypertrophy, cardiomyopathy , central line infection, cyanosis, deafness neurosensory, disease progression, electromyogram abnormal, hypotension, hypotonia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with CORTICOSTEROIDS, PHENERGAN, HYDROCORTISONE. Patient was hospitalized and became disabled. Patient recovered.

Myozyme Side Effects Report #6028578-5
Myozyme side effect was reported by a Physician from ISRAEL on Dec 22, 2008. Male patient, child 2 years of age, weighting 26.46 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory failure, central line infection, deafness neurosensory, disease progression, electromyogram abnormal, hypertrophic cardiomyopathy, hypotension, hypotonia, infusion related reaction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with CORTICOSTEROIDS, PHENERGAN, HYDROCORTISONE, ASPIRIN. Patient was hospitalized and became disabled. Patient recovered.

Myozyme Side Effects Report #5339799-9
Myozyme side effect was reported by a Physician from UNITED STATES on May 11, 2007. Male patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: apnoea, bronchospasm, disease recurrence, hypotension, oxygen saturation decreased, wheezing. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5425662-1
Myozyme side effect was reported by a Physician from UNITED STATES on May 25, 2007. Female patient, child 1 years of age, weighting 30.86 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: hypotension. Myozyme dosage: 20 MG, KG, Q2WKS; IV. Patient recovered.

Myozyme Side Effects Report #5255199-4
Myozyme side effect was reported by a Physician from ITALY on Feb 14, 2007. Female patient, weighting 14.33 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: central line infection, cyanosis, hypotension, oxygen saturation decreased, viral infection . Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.


Myozyme Side Effects Report #5293817-5
Myozyme side effect was reported by a Physician from ITALY on Mar 22, 2007. Female patient, weighting 14.33 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: central line infection, cyanosis, hypotension, infusion related reaction, oxygen saturation decreased. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5081197-X
Myozyme side effect was reported by a Physician from UNITED STATES on July 27, 2006. Female patient, weighting 22.07 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, atelectasis, bacterial culture positive, bronchiolitis, hypotension, hypoventilation, klebsiella infection, left ventricle outflow tract obstruction, listless. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5117729-2
Myozyme side effect was reported by a Physician from BRAZIL on Sept 12, 2006. Female patient, weighting 15.43 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: body temperature decreased, hypotension, infusion related reaction. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with CAPTOPRIL, FUROSEMIDE, DIGOXIN, CARVEDILOL. Patient recovered.

Myozyme Side Effects Report #5384925-9
Myozyme side effect was reported by a Physician from UNITED STATES on June 25, 2007. Male patient, weighting 13.01 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, bronchial hyperreactivity, candidiasis, central line infection, eosinophilia, hypotension, influenza, renal failure acute. Myozyme dosage: 10 MG/KG Q2WKS IV. During the same period patient was treated with DIGOXIN, POTASSIUM CHLORIDE, CALCIUM GLUBIONATE, PROCRIT, BENADRYL, TYLENOL, FERROUS SULPHATE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5394686-5
Myozyme side effect was reported by a Physician from UNITED STATES on July 09, 2007. Male patient, weighting 13.01 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, bronchial hyperreactivity, candidiasis, central line infection, enzyme inhibition, eosinophilia, hypotension, influenza serology positive. Myozyme dosage: 10 MG/KG QWKS IV. During the same period patient was treated with METHOTREXATE, CAPTOPRIL, FUROSEMIDE, DIGOXIN, POTASSIUM CHLORIDE, CALCIUM GLUBIONATE, PROCRIT. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5768470-4
Myozyme side effect was reported by a Physician from ISRAEL on June 03, 2008. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac hypertrophy, central line infection, cyanosis, deafness neurosensory, disease progression, electromyogram abnormal, hypotension, hypotonia. Myozyme dosage: unknown. During the same period patient was treated with CORTICOSTEROIDS, PHENERGAN, HYDROCORTISONE. Patient was hospitalized and became disabled. Patient recovered.

Myozyme Side Effects Report #5930832-X
Myozyme side effect was reported by a Physician from KUWAIT on Oct 16, 2008. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, coma, hypotension, pneumonia , pyrexia, respiratory distress, tachycardia, wheezing. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS. During the same period patient was treated with VENTOLIN, LASIX, ALDACTONE, CAPTOPRIL, DOPAMINE. Patient was hospitalized and became disabled. Patient died on 07/18/2008.

Myozyme Side Effects Report #6060120-5
Myozyme side effect was reported by a Physician from UNITED ARAB EMIRATES on Jan 15, 2009. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspartate aminotransferase increased, blood creatine phosphokinase increased, blood lactate dehydrogenase increased, cardiac failure, hypotension, respiratory distress. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6070363-2
Myozyme side effect was reported by a Physician from UNITED ARAB EMIRATES on Jan 28, 2009. Male patient, weighting 5.95 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase decreased, aspartate aminotransferase increased, blood creatine phosphokinase increased, blood lactate dehydrogenase increased, cardiac failure, dilatation ventricular, enzyme abnormality, hypotension, respiratory distress. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6111297-4
Myozyme side effect was reported by a Physician from GREECE on Feb 27, 2009. Male patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cyanosis, erythema, hypersensitivity, hypotension, infusion related reaction, pruritus, rash . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #6111696-0
Myozyme side effect was reported by a Pharmacist from UNITED STATES on Mar 10, 2009. Male patient, weighting 38.80 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anxiety , flushing, hypotension, hypoxia, infusion related reaction, tachycardia. Myozyme dosage: 350 MG EVERY 2 WEEKS IV DRIP. Patient was hospitalized. Patient recovered.