Myozyme and muscular weakness Patient Reports February 10, 2010

Myozyme Side Effects Report #6112212-X
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 25, 2009. Male patient, child 9 years of age, weighting 72.53 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: disease progression, dysstasia, fatigue, movement disorder , muscular weakness, peroneal nerve palsy, restrictive pulmonary disease. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS; 5 MG/KG, 2X/W, INTRAVENOUS; 10 MG/KG, QW. Patient recovered.

Myozyme Side Effects Report #5633193-9
Myozyme side effect was reported by a Physician from FRANCE on Feb 01, 2008. Female patient, 74 years of age, weighting 177.7 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure increased, bundle branch block left, cardiac arrest , dysarthria, fall , lung disorder, meningioma, muscular weakness, musculoskeletal disorder. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5975623-9
Myozyme side effect was reported by a Physician from ISRAEL on Nov 17, 2008. Female patient, child 6 years of age, weighting 41.45 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , asthenia, developmental delay, diarrhoea, face oedema, irritability, muscular weakness, myopathy, no therapeutic response. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5752264-X
Myozyme side effect was reported by a Physician from UNITED STATES on May 12, 2008. Female patient, 53 years of age, weighting 131.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arthralgia, gait disturbance, headache , ligament disorder, malaise, muscle atrophy, muscular weakness, nausea . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with EPHEDRINE SULPHATE, VITAMIN, CALCIUM, VITAMIN D, DIMENHYDRINATE, PSEUDOEPHEDRINE HYDROCHLORIDE, OXYMETAZOLINE. Patient recovered.


Myozyme Side Effects Report #5778476-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on June 03, 2008. Female patient, 53 years of age, weighting 131.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arthralgia, asthenia, balance disorder, gait disturbance, headache , muscular weakness, nausea , neuralgia, tinnitus . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with EPHEDRINE SULPHATE, VITAMIN, CALCIUM, VITAMIN D. Patient recovered.

Myozyme Side Effects Report #5901985-4
Myozyme side effect was reported by a Health Professional from UNITED STATES on Sept 15, 2008. Female patient, 46 years of age, weighting 222.7 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: disease progression, muscular weakness, urinary tract infection . Myozyme dosage: 20 MG, Q2W, INTRAVENOUS. During the same period patient was treated with VICODIN, DARVOCET, IRON, FENUGREEK, VITAMIN. Patient recovered.

Myozyme Side Effects Report #5201827-9
Myozyme side effect was reported by a Physician from HUNGARY on Dec 21, 2006. Female patient, 43 years of age, weighting 114.6 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal distension, dizziness , dyspnoea, fall , fatigue, hyperhidrosis, hypertension, muscular weakness, pallor. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with SUPRASTIN. Patient recovered.

Myozyme Side Effects Report #5233627-8
Myozyme side effect was reported by a Physician from HUNGARY on Jan 24, 2007. Female patient, 43 years of age, weighting 114.6 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal distension, anaphylactic reaction, fall , fatigue, muscular weakness, poor peripheral circulation. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with SUPRASTIN, TELFAST, CALCIUM GLUCONATE. Patient recovered.

Myozyme Side Effects Report #5424571-1
Myozyme side effect was reported by a Health Professional from UNITED STATES on Apr 02, 2007. Female patient, 35 years of age, weighting 156.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: feeling hot, muscular weakness. Myozyme dosage: 20 MG/KG IV. During the same period patient was treated with CARNITOR, IBUPROFEN. Patient recovered.


Myozyme Side Effects Report #5454997-1
Myozyme side effect was reported by a Physician from AUSTRALIA on Aug 30, 2007. Female patient, child 3 years of age, weighting 33.73 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood creatine phosphokinase increased, diarrhoea, dysphagia, fall , fatigue, muscular weakness. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient recovered.

Myozyme Side Effects Report #5506909-X
Myozyme side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 18, 2007. Female patient, child 3 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: hyperparathyroidism, infusion related reaction, muscular weakness, oxygen saturation decreased, urinary tract infection . Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5455028-X
Myozyme side effect was reported by a Physician from CHINA on Aug 30, 2007. Female patient, child 2 years of age, weighting 13.87 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, condition aggravated, disease recurrence, muscular weakness, myocardial ischaemia, no therapeutic response, nodal arrhythmia, pneumonia , ventricular extrasystoles. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5738427-8
Myozyme side effect was reported by a Physician from UNITED STATES on Apr 30, 2008. Male patient, child 2 years of age, weighting 30.86 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: disease progression, hypokinesia, muscular weakness, nystagmus, respiratory failure. Myozyme dosage: unknown. During the same period patient was treated with ASPIRIN, COREG, LASIX, ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE, RANITIDINE. Patient recovered.

Myozyme Side Effects Report #5216598-X
Myozyme side effect was reported by a Consumer or non-health professional from CANADA on Jan 04, 2007. Male patient, 15 years of age, weighting 96.12 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: accident, muscular weakness, pneumonia , scoliosis, therapeutic response decreased, wrist fracture. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, PAMIDRONATE DI, CALCIUM. Patient recovered.


Myozyme Side Effects Report #5467536-6
Myozyme side effect was reported by a Physician from UNITED STATES on Sept 10, 2007. Female patient, 14 years of age, weighting 116.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: fatigue, muscular weakness. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient recovered.

Myozyme Side Effects Report #5794336-X
Myozyme side effect was reported by a Physician from UNITED STATES on June 19, 2008. Male patient, child 12 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, arthralgia, chest pain , dehydration, eye rolling, heart rate increased, muscular weakness, nasal congestion, rocky mountain spotted fever. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5330165-9
Myozyme side effect was reported by a Physician from UNITED STATES on May 02, 2007. Male patient, child 1 years of age, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: disease recurrence, muscular weakness, respiratory failure. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5945734-2
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Oct 22, 2008. Male patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: hypokinesia, muscular weakness, pyrexia, social avoidant behaviour. Myozyme dosage: unknown. Patient recovered.

Myozyme Side Effects Report #5218783-X
Myozyme side effect was reported by a Health Professional from UNITED STATES on Jan 09, 2007. Male patient, weighting 11.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: glycogen storage disease type ii, hypotonia, muscular weakness, oral intake reduced, pneumonia , respiratory distress, sleep apnoea syndrome, stomatitis. Myozyme dosage: 130 MG Q2WKS IV. During the same period patient was treated with ALBUTEROL, PROPRANOLOL, ZANTAC. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5236946-4
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 26, 2007. Male patient, weighting 11.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: carbon dioxide increased, cardiomegaly, muscular weakness, pneumonia , respiratory distress, sleep apnoea syndrome. Myozyme dosage: 130 MG Q2WKS IV. During the same period patient was treated with ALBUTEROL, PROPRANOLOL, ZANTAC. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5362893-3
Myozyme side effect was reported by a Physician from UNITED STATES on June 01, 2007. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: influenza, left ventricular hypertrophy, muscular weakness, pneumonia aspiration, respiratory failure, respiratory tract infection viral, upper respiratory tract infection. Myozyme dosage: 150 MG Q2WKS IV. During the same period patient was treated with LASIX, ENALAPRIL, XOPENEX, PULMICORT, PREVACID. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5160220-8
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 06, 2006. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: condition aggravated, conjunctival hyperaemia, disease progression, erythema, flushing, hypertrophic cardiomyopathy, infusion related reaction, muscular weakness, nausea . Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5637776-1
Myozyme side effect was reported by a Health Professional from UNITED STATES on Feb 07, 2008. Female patient, weighting 20.94 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: disease progression, glycogen storage disease type ii, muscular weakness, pyrexia. Myozyme dosage: 20 MG/KG, Q2W,INTRAVENOUS. Patient died on 08/30/2007.

Myozyme Side Effects Report #5659994-9
Myozyme side effect was reported by a Health Professional from UNITED STATES on Mar 03, 2008. Female patient, weighting 20.94 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiopulmonary failure, disease progression, muscular weakness, no therapeutic response, pyrexia, refusal of treatment by relative. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient died on 08/30/2007.


Myozyme Side Effects Report #5688181-3
Myozyme side effect was reported by a Physician from BELGIUM on Mar 13, 2008. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: condition aggravated, glycogen storage disease type ii, muscular weakness, respiratory failure. Myozyme dosage: unknown. Patient died on 12/21/2007.

Myozyme Side Effects Report #5811792-9
Myozyme side effect was reported by a Physician from NETHERLANDS on July 03, 2008. Male patient, weighting 198.4 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: disease progression, fall , fatigue, hypercapnia, muscular weakness. Myozyme dosage: 20 MG/KG, Q2W. During the same period patient was treated with CLEMANIL, HYDROCORTISONE. Patient recovered.

Myozyme Side Effects Report #5888718-5
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Sept 08, 2008. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: antibody test positive, congestive cardiomyopathy, muscular weakness, respiratory failure, respiratory tract infection. Myozyme dosage: 100 MG Q2W INTRAVENOUS; 100 MG Q2W INTRAVENOUS; 20 MG/KG QW INTRAVENOUS. During the same period patient was treated with DESLORATADINE, ASPIRIN, CAPTOPRIL, CARVEDILOL, FUROSEMIDE. Patient recovered.

Myozyme Side Effects Report #5912760-9
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Sept 29, 2008. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: congestive cardiomyopathy, infusion related reaction, muscular weakness, respiratory failure, respiratory tract infection. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS; 20 MG/KG, QW, INTRAVENOUS. During the same period patient was treated with DESLORATADINE, ASPIRIN, CAPTOPRIL, CARVEDILOL, FUROSEMIDE. Patient recovered.

Myozyme Side Effects Report #5945735-4
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Oct 31, 2008. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, congestive cardiomyopathy, malaise, muscular weakness, respiratory failure, respiratory tract infection. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS; 100 MG, Q2W, INTRAVENOUS; 20 MG/KG, QW, INTRAVENOUS. During the same period patient was treated with DESLORATADINE, ASPIRIN, CAPTOPRIL, CARVEDILOL, FUROSEMIDE. Patient recovered.


Myozyme Side Effects Report #5963759-8
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Nov 14, 2008. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: hypokinesia, muscular weakness, pyrexia, social avoidant behaviour. Myozyme dosage: 20 MG/KG Q2W INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5976517-5
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Nov 11, 2008. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: congestive cardiomyopathy, muscular weakness, respiratory failure, respiratory tract infection. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS; 100 MG, Q2W, INTRAVENOUS; 20 MG/KG, QW, INTRAVENOUS. During the same period patient was treated with DESLORATADINE, ASPIRIN, CAPTORIL, CARVEDILOL, FUROSEMIDE. Patient died on 11/05/2008.

Myozyme Side Effects Report #5989754-0
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Dec 02, 2008. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, cytomegalovirus infection , hypokinesia, muscular weakness, pyrexia, social avoidant behaviour. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #6021203-9
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Dec 15, 2008. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cytomegalovirus infection , hypokinesia, muscular weakness, parainfluenzae virus infection, social avoidant behaviour. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #6088082-5
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Feb 09, 2009. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, cardiac hypertrophy, cardiomegaly, cardiopulmonary failure, congestive cardiomyopathy, infusion related reaction, muscular weakness, respiratory failure. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS; 20 MG/KG, QW, INTRAVENOUS. During the same period patient was treated with DESLORATADINE, ASPIRIN, CAPTOPRIL, CARVEDILOL, FUROSEMIDE. Patient died on 11/05/2008.