Orfadin and thrombocytopenia Patient Reports February 09, 2010

Orfadin Side Effects Report #5269487-9
Orfadin side effect was reported by a Physician from FRANCE on Feb 23, 2007. Male patient was diagnosed with tyrosinaemia and was treated with Orfadin. After drug was administered, patient experienced the following side effects: haemoglobin decreased, neutropenia, purpura, pyrexia, thrombocytopenia, white blood cell count increased. Orfadin dosage: 0.5 MG/KG TWICE DAILY ORAL. During the same period patient was treated with LASIX, ALDACTONE, PHOSPHORE, CALCIUM SUPP, DOLIPRANE. Patient recovered.

Orfadin Side Effects Report #5081655-8
Orfadin side effect was reported by a Consumer or non-health professional from FRANCE on July 21, 2006. Male patient was diagnosed with tyrosinaemia and was treated with Orfadin. After drug was administered, patient experienced the following side effects: ascites, haemoglobin decreased, neutropenia, purpura, pyrexia, thrombocytopenia. Orfadin dosage: 0.5 MG/KG TWICE DAILY ORAL. During the same period patient was treated with LASILIX, ALDACTONE, PHOSPHORE, CALCIUM SUPP, DOLIPRANE. Patient recovered.

Orfadin Side Effects Report #5914482-7
Orfadin side effect was reported by a Consumer or non-health professional from on Sept 23, 2008. Female patient, weighting 15.43 lb, was diagnosed with tyrosinaemia and was treated with Orfadin. After drug was administered, patient experienced the following side effects: condition aggravated, hepatic failure, leukopenia, thrombocytopenia. Orfadin dosage: 1, 6 MG/KG, ORAL. During the same period patient was treated with GANCICLOVIR. Patient died.

Orfadin Side Effects Report #5940669-3
Orfadin side effect was reported by a Consumer or non-health professional from on Oct 14, 2008. Female patient, weighting 15.43 lb, was diagnosed with tyrosinaemia and was treated with Orfadin. After drug was administered, patient experienced the following side effects: condition aggravated, hepatic failure, leukopenia, thrombocytopenia. Orfadin dosage: 1,6 MG/KG, ORAL. During the same period patient was treated with GANCICLOVIR. Patient died.


Orfadin Side Effects Report #5954622-7
Orfadin side effect was reported by a Consumer or non-health professional from ARGENTINA on Oct 27, 2008. Female patient was diagnosed with tyrosinaemia and was treated with Orfadin. After drug was administered, patient experienced the following side effects: condition aggravated, no therapeutic response, thrombocytopenia. Orfadin dosage: 2 MG/KG, ORAL. During the same period patient was treated with GANCICLOVIR, VANCOMYCIN, IMIPENEM, COLISTIN, METRONIDAZOLE, NEOMYCINE, CLONIDINE, MIDAZOLAM. Patient died on 09/28/2008.

Orfadin Side Effects Report #4755113-1
Orfadin side effect was reported by a Physician from FRANCE on Aug 10, 2005. Male patient, weighting 1.00 lb, was diagnosed with tyrosinaemia and was treated with Orfadin. After drug was administered, patient experienced the following side effects: ascites, haemoglobin decreased, neutropenia, pyrexia, thrombocytopenia. Orfadin dosage: 0.5 MG/KG TWICE DAILY ORAL. During the same period patient was treated with LASILIX, ALDACTONE, PHOSPHORE, DOLIPRANE. Patient recovered.