Rasburicase and hepatic failure Patient Reports February 10, 2010

Rasburicase Side Effects Report #4651407-9
Rasburicase side effect was reported by a Consumer or non-health professional from on Apr 08, 2005. Female patient, 70 years of age, weighting 126.3 lb, was diagnosed with hyperuricaemia, leukaemia, lymphoma , tumour lysis syndrome and was treated with Rasburicase. After drug was administered, patient experienced the following side effects: cardiac arrest , cholelithiasis, gastrointestinal haemorrhage, haematuria, hepatic failure, hepatotoxicity, platelet count decreased, pulmonary haemorrhage, refusal of treatment by relative. Rasburicase dosage: 0.2 MG/KG QD - INTRAVENOUS NOS. During the same period patient was treated with ALLOPURINOL, VANCOMYCIN, CEFTAZIDIME, NAFCILLIN, ACYCLOVIR. Patient died on 11/16/2004.

Rasburicase Side Effects Report #4639249-1
Rasburicase side effect was reported by a Health Professional from on Oct 29, 2004. Female patient, weighting 126.3 lb, was diagnosed with hyperuricaemia and was treated with Rasburicase. After drug was administered, patient experienced the following side effects: cardiac arrest , gallbladder disorder, gastrointestinal haemorrhage, haematuria, hepatic failure, hepatitis b , hepatotoxicity, platelet count decreased, pulmonary haemorrhage. Rasburicase dosage: unknown. During the same period patient was treated with ALLOPURINOL, VANCOMYCIN, FORTAZ, NAFCILLIN, ACYCLOVIR, SPORANOX, CIPROFLOXACIN. Patient died on 11/16/2004.