Vorinostat and syncope Patient Reports February 10, 2010

Vorinostat Side Effects Report #5744666-2
Vorinostat side effect was reported by a Physician from UNITED STATES on Apr 30, 2008. Female patient, 71 years of age, weighting 152.0 lb, was diagnosed with acute myeloid leukaemia, rosacea , hyperlipidaemia, acute leukaemia, myelodysplastic syndrome, hypertension, antibiotic prophylaxis and was treated with Vorinostat. After drug was administered, patient experienced the following side effects: asthenia, bundle branch block right, electrocardiogram qt prolonged, nausea , oral disorder, syncope, treatment noncompliance. Vorinostat dosage: 400 MG/DAILY/PO. During the same period patient was treated with DOXYCYCLINE, GEMFIBROZIL, DECITABINE, BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE, AVELOX. Patient was hospitalized. Patient recovered.

Vorinostat Side Effects Report #5869283-5
Vorinostat side effect was reported by a Physician from UNITED STATES on Aug 15, 2008. Female patient, 71 years of age, weighting 152.0 lb, was diagnosed with acute myeloid leukaemia, myelodysplastic syndrome, rosacea , hyperlipidaemia and was treated with Vorinostat. After drug was administered, patient experienced the following side effects: asthenia, bundle branch block right, hypophagia, nausea , syncope, syncope vasovagal, urinary tract obstruction. Vorinostat dosage: 400 MG/DAILY/PO. During the same period patient was treated with DOXYCYCLINE, GEMFIBROZIL, DECITABINE. Patient was hospitalized. Patient recovered.